Selumitinib Medication Information

Discover comprehensive details about Selumitinib, including its pronunciation, uses, dosage instructions, indications, and guidelines on how and when to take it or avoid it.

The updated prescription information covers potential side effects, precautions, warnings, and storage recommendations.

Additionally, explore the Selumitinib brands available in India and internationally, along with pricing information. For personalized advice, consult your healthcare provider.

Generic Name : Selumitinib

Pronunciation : SEL ue MET i nib

Brand Names or Trade Names of Selumitinib

India :

KOSELUGO

Overview of Selumitinib

Selumitinib is a kinase inhibitor approved for treating children aged over two years treatment of with Neuro-Fibromatosis Type 1 (NF1). It is a genetic disorder that causes skin pigmentation and tumors in the nerves under the skin, in the brain, and in other areas of the body.

Why is Selumitinib Prescribed? (Indications)

Selumitinib is a kinase inhibitor approved for treating children aged above two years treatment of with Neuro-Fibromatosis Type 1 (NF1). It is prescribed for patients with NF1 who have symptoms and who are not suitable for surgical management.

When should Selumitinib not be taken? (Contraindications)

Patients allergic to Selumitinib

What is the dosage of Selumitinib?

Selumitinib is available as capsules: 10 mg and 25 mg.
The recommended dosage is 25 mg be to taken by mouth two times a day

How should Selumitinib be taken?

Selumitinib should be taken on an empty stomach.
Food should not be taken 2 hours before or 1 hour after the dose.
The drug should be taken at same time each day at 12 hours apart.

Missed a Dose?

The missed dose should not be taken unless it is more than 6 hours until the next scheduled dose. In case of vomiting after the drug administration, do not take an additional dose, but continue with the next scheduled dose.

What are the warnings and precautions for Selumitinib?

•1. Withhold, reduce dose, or discontinue Selumitinib is there is any adverse reaction like enlargement of the heart called cardiomyopathy.

• 2. Regular eye assessments should be done prior to starting selumitinib, to detect any new or worsening visual changes in the retina.

• 3. It may increase the incidence of diarrhea or loose stools. Patients should start an anti-diarrheal agent immediately after the 1st episode of diarrhea.

• 4. The drug may cause skin reactions. In that case, withhold or reduce dose or permanently stop the drug, based on severity of adverse reaction.

• 5. Patients should be monitored using Creatinine Phosphokinase (CPK) - a blood test regularly.

• 6. Selumitinib capsules contains vitamin E and the dose may exceed the recommended or safe limits. It may increase the chance of bleeding. So proper vitamin K intake is recommended.

• 7. Reduce the dose in case of liver impairment.

What are the side effects of Selumitinib?

1. General: Fever, headache
2. Heart: increased heart rate, swelling around ankles, tiredness
3. Skin: Itching, dry skin, redness around fingernails
4. Digestive: Vomiting, nausea, stomach pain, diarrhea
5. Musculoskeletal: Muscle and bone pain

What are the other precautions for Selumitinib?

• Patients should inform doctor if they are pregnant or planning to become pregnant.
• In women who are of child bearing age, they should use proper contraceptives during the treatment period and for one week after the last dose is given to avoid pregnancy.
• Males with female partners should also use effective birth control.
• Inform healthcare providers in case of breastfeeding or plan to breastfeed.
• Patients should inform about all medicines they are using including over-the-counter medicines, vitamins, or herbal supplements.
• Patients who are taking blood thinners may be at increased risk of bleeding.