Siponimod Medication Information

Get detailed information on Siponimod, including pronunciation, uses, dosage guidelines, indications, and instructions on how and when to take it and when to avoid it.

The updated prescription information on Siponimod provides an overview of possible side effects, precautions, warnings, and storage tips.

You'll also find brand names used in india and internationally, along with pricing details. For further clarification, consult your healthcare provider.

Generic Name : Siponimod

Pronunciation : si-PON-i-mod

Trade Names/Brand Names of Siponimod

India :

Mayzent

Overview of Siponimod

Siponimod is used for treating an immune disorder named Multiple Sclerosis (MS), especially for relapsing-remitting disease among adult patients.

Why is Siponimod Prescribed? (Indications)

Siponimod is used for treating an immune disorder named Multiple Sclerosis (MS), especially for relapsing-remitting disease among adult patients.

When should Siponimod not be taken? (Contraindications)

1. Hypersensitivity to Siponimod
2. Patients with a genetic abnormality (CYP2C93/3 genotype)
3. Patients with a hospitalization history for heart attack, stroke, heart failure in the last 6 months
4. Patients with heart block.

What is the dosage of Siponimod?

The recommended initial dose is 2 mg once daily.
The recommended maintenance dosage is 1 mg once daily. The dose should be increased gradually.
Since MS is an immune disorder, Siponimod should be taken over a long period of time under the instruction of the doctor and one should regularly visit the doctor to ensure safety of the medication.

How should Siponimod be taken?

Siponimod is to be taken orally. They are available as 0.25 mg and 2 mg tablets.

Missed a Dose?

In case of missing a dose after initial dose-titration, the drug should be taken as soon as you remember.

What are the side effects of Siponimod?

o General: Headache, Infections, Decreased immunity
o Eye: Macular swelling
o Heart: Low heart rate, conduction abnormalities
o Gastrointestinal: Liver injury (raised liver enzymes)
o Vascular: Increased blood pressure
o Respiratory: Decreased lung capacity.

What are the other precautions for Siponimod?

1. Siponimod may increase the chance of infections. So, obtain a complete blood count (CBC) before initiating treatment.
2. Eye evaluation is recommended before starting treatment as there is an increased chance of macular swelling
3. Siponimod may lower heart rate. So, get cardiologist consultation before concomitant use with other drugs that decrease heart rate.
4. Siponimod may cause a decline in lung function. So, assess pulmonary function before starting the drug.
5. Check liver enzymes before initiation of drug.
6. Monitor BP frequently during treatment.
7. Women of childbearing potential should use effective contraception during and for 10 days after stopping Siponimod.

What are the Drug Interactions of Siponimod?

Siponimod will interact with the following drugs:
• Quinidine, Procainamide, Amiodarone, Sotalol
• Propranolol
• Fluconazole
• Rifampin
• Carbamazepine etc.