Sirolimus Medication Information

Learn everything you need to know about Sirolimus-pronunciation, uses, dosage guidelines, indications, and when to take or avoid it.

Get up-to-date information on side effects, precautions, warnings, and proper storage to ensure safe usage.

Explore Sirolimus brand names commonly used in India and internationally, along with detailed pricing information. Consult your healthcare provider for tailored medical advice.

Generic Name : Sirolimus

Pronunciation : sir-OH-li-mus

ICD Code : Y43.4 Therapeutic Classification : Immunosuppressants

Brand Names or Trade Names of Sirolimus

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International :

Rapamune, Siromus, Rapacan

Why is Sirolimus Prescribed? (Indications)

This medication is an immunosuppressant, prescribed for preventing rejection of kidney transplants either alone or with other medications. It works by suppressing the body's immune system.

When should Sirolimus not be taken? (Contraindications)

Hypersensitivity.

What is the dosage of Sirolimus?

Adult: PO- Low-moderate risk patients: 6 mg on day 1. Maintenance: 2 mg once daily, given 4 hour after ciclosporin.
High immunological risk patients: Recommended loading dose: 15 mg. Maintenance: 5 mg/day.

How should Sirolimus be taken?

It comes as a tablet to take by mouth, on an empty stomach or with food.

What are the warnings and precautions for Sirolimus?

•♦ Caution should be exercised in patients with history of liver, kidney problems, high cholesterol, low blood platelet levels, diabetes, lung or breathing problems, any allergy, infections, who are taking other medications especially for HIV or Hepatitis C , during pregnancy and breastfeeding.

• Avoid contact with people who have infections.

• Patient may develop with increased risk of progressive multifocal leukoencephalopathy (PML), severe kidney problems, certain types of cancer; if it is so consult with your doctor.

• Avoid live vaccination while taking this medication.

• It may affect blood sugar level; monitor sugar level regularly while taking this medication.

What are the side effects of Sirolimus?

Most Common - Swelling in the extremities, high blood pressure, increased cholesterol level, constipation, abdominal pain, diarrhea, headache, fever, urinary tract infection, anemia, nausea, joint pain, and decrease in platelet counts.
Body as a Whole - Sepsis and infections.
Heart - Blood clot events and fast heart rate.
Gastrointestinal - Mouth ulcer.
Metabolic- Abnormal healing, increased level of lactic dehydrogenase (LDH) and decrease in blood potassium level.
Musculoskeletal - Death of bone cells.
Respiratory - Nose bleed and lung infection.
Skin - Skin cancer and rash.
Genitourinary - Kidney inflammation.