Telotristat ethyl Medication Information

Get detailed information on Telotristat ethyl, including pronunciation, uses, dosage guidelines, indications, and instructions on how and when to take it and when to avoid it.

The updated prescription information on Telotristat ethyl provides an overview of possible side effects, precautions, warnings, and storage tips.

You'll also find brand names used in india and internationally, along with pricing details. For further clarification, consult your healthcare provider.

Generic Name : Telotristat ethyl

Pronunciation : tel-OH-tri-stat-ETH-il

Therapeutic Classification : Antidiarrheals

Trade Names/Brand Names of Telotristat ethyl

India :

Xermelo

Overview of Telotristat ethyl

• Telotristat ethyl is the first oral drug which was approved by the US FDA for treating carcinoid syndrome diarrhea.

Why is Telotristat ethyl Prescribed? (Indications)

Telotristat ethyl, a tryptophan hydroxylase inhibitor, is prescribed for the treatment of carcinoid syndrome diarrhea in combination with somatostatin analog (SSA) in adults who shows inadequate response to SSA therapy alone.

Telotristat ethyl works by blocking the production of serotonin in the body and thereby reduces the frequency of bowel movements in patients with carcinoid syndrome.
Patients who suffer from carcinoid syndrome have high serotonin levels, which leads to diarrhea or frequent bowel symptoms, stomach pain, warmth, redness or tingly feeling.

When should Telotristat ethyl not be taken? (Contraindications)

Telotristat ethyl is not recommended in:

• Patients with hypersensitivity or allergy to telotristat ethyl
• Children under 18 years of age

What is the dosage of Telotristat ethyl?

• 250mg three times a day along with somatostatin analog therapy.

How should Telotristat ethyl be taken?

• Telotristat ethyl comes as a tablet to be taken by mouth with food.
• Telotristat tablets come in a monthly case which contains 4 weekly boxes. Each box contains 7 daily doses for a week.

Missed a Dose?

• If a dose is missed, take it as soon as you remember. If it is almost time for the next scheduled dose, skip the missed dose and take the next scheduled dose at the specified time.
• Do not double the dose to make up for the missed one.

What are the warnings and precautions for Telotristat ethyl?

• Telotristat ethyl treatment should be discontinued in cases of severe constipation or worsening stomach pain since it could indicate intestinal obstruction or perforation.

• Patients who are also prescribed octreotide must take octreotide half an hour after taking telotristat ethyl.

• Telotristat ethyl is a part of a complete treatment program that includes other medications and should be taken strictly as advised by the physician. They should not be shared with another person even if the symptoms are the same.

• Telotristat ethyl should be used with caution in end stage kidney disease or moderate-to-severe liver disease since it has not been adequately studied in these populations.

What are the side effects of Telotristat ethyl?

Gastrointestinal: Nausea, loss of appetite, bloating or excess gas production, liver function tests abnormalities, constipation, abdominal pain, rarely bowel obstruction or intestinal perforation
Central nervous system: Headache, depression
Cardiovascular: Peripheral edema (swelling of hands or feet)
Others: Fecaloma or fecal impaction, fever, allergic reaction

What are the other precautions for Telotristat ethyl?

• All the tablets should be kept in their original package.
• The tablets of telotristat ethyl should not be taken either in smaller or larger amounts or for longer periods than recommended.
• Pregnant and breastfeeding mothers should take telotristat ethyl tablets only after the approval of a medical specialist and require close and careful monitoring while on the treatment.

What are the Drug Interactions of Telotristat ethyl?

• Telotristat ethyl tablets should be avoided with midazolam, clozapine, hydrocodone or nimodipine as their effects are greatly reduced by telotristat ethyl.
• Short-acting octreotide decreases the effect of telotristat ethyl and should be administered 30 minutes after telotristat ethyl.
• The level of fexofenadine has been found to be increased when taken along with telotristat ethyl tablets.

What are the storage conditions for Telotristat ethyl?

• Telotristat ethyl tablets should be stored at a room temperature (15°C to 25°C)
• They should be stored in its original carton and keep out of reach of the children.