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Temozolomide - Indications, Dosage, Side Effects and Precautions

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Temozolomide Medication Information

Learn everything you need to know about Temozolomide-pronunciation, uses, dosage guidelines, indications, and when to take or avoid it.

Get up-to-date information on side effects, precautions, warnings, and proper storage to ensure safe usage.

Explore Temozolomide brand names commonly used in India and internationally, along with detailed pricing information. Consult your healthcare provider for tailored medical advice.

Generic Name : Temozolomide
Pronunciation : TEM-oh-ZOE-loe-mide

Brand Names or Trade Names of Temozolomide

India :

International :


Temodar

Why is Temozolomide Prescribed? (Indications)

This medication is an anticancer agent, used for brain cancers i.e. anaplastic astrocytoma and glioblastoma multiforme. It is also used for treating melanoma.  It slows or stops the growth of cancer cells in the body.

When should Temozolomide not be taken? (Contraindications)

Hypersensitivity.

What is the dosage of Temozolomide?

Anaplastic astrocytoma: The starting dose is 150 mg/m2 once daily for first 5 days in 28days cycle. It may be adjusted depending upon blood counts. Max: 200 mg/m2/day.
Metastatic melanoma: The dose is given in range of 150 – 200mg/m2 once daily for first 5 days in 28days cycle, as a single therapy.

How should Temozolomide be taken?

It comes as a capsule to take by mouth, should be taken on an empty stomach.

What are the warnings and precautions for Temozolomide?

•Use a reliable method of birth control to prevent pregnancy. It may harm the fetus.

It may increase your risk of developing a second cancer.Contact your doctor immediately.

Monitor complete blood count, Pneumocystis carinii pneumonia (PCP) development regularly.

Caution should be exercised in patients with history of liver or kidney disease, pregnancy, elderly greater than 70 yrs, children.

It may cause dizziness or drowsiness. Do not drive a car or operate machinery while taking this medication.

What are the side effects of Temozolomide?

Most common- Hair loss, fatigue, nausea, vomiting, headache, constipation, loss of appetite, convulsions, rash, weakness, diarrhea, weakness, fever, dizziness, abnormal coordination, viral infection, memory loss, and sleeplessness.
Central Nervous System- Convulsions, dizziness, tingling, drowsiness, incoordination, confusion, anxiety, depression.
Blood- Decrease in number of all blood cells.
Endocrine- Adrenal hypercorticism.
Gastrointestinal - Nausea, vomiting, constipation, diarrhea, abdominal pain, loss of appetite.
Musculoskeletal - Muscle pain.
Respiratory- Upper respiratory tract infection, inflammation of pharynx, sinusitis, coughing.
Skin- Rash, itching.
Genitourinary- Urinary tract infection, increased frequency.
Eye- Double vision, vision abnormal.

What are the other precautions for Temozolomide?

Avoid using contaminated solution of this medication.

What are the storage conditions for Temozolomide?

Oral: Store at 15-30°C. Store it at room temperature and away from excess heat and moisture.

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