Are you taking Alprazolam? Are you aware of the dangers of combining Alprazolam with certain foods, herbs, or alcohol? Drug-food-interactions are seldom discussed but can lead to undesirable side effects and potentially diminish the efficacy of the medication.
Effects of repeated ingestion of grapefruit juice on the single and multiple oral-dose pharmacokinetics and pharmacodynamics of alprazolam
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Kava : Alprazolam interacts with Kava (Piper methysticum) resulting in excessive drowsiness.
Hypericum species (St. John's wort) : St.John's Wort interacts with alprazolam and lowers the plasma level of the drug thereby reducing its therapeutic effect (2✔ ✔Trusted Source
Herb–Drug Interactions with St John’s Wort (Hypericum perforatum): an Update on Clinical Observations
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Influence of ethanol on the metabolism of alprazolam
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Alprazolam: Medlineplus Drug Information
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References
Alprazolam Interactions with Food and Herbs
Grapefruit Juice: Grapefruit juice may increase the concentration of alprazolam in the blood (1✔ ✔Trusted SourceEffects of repeated ingestion of grapefruit juice on the single and multiple oral-dose pharmacokinetics and pharmacodynamics of alprazolam
Go to source).
Kava : Alprazolam interacts with Kava (Piper methysticum) resulting in excessive drowsiness.
Hypericum species (St. John's wort) : St.John's Wort interacts with alprazolam and lowers the plasma level of the drug thereby reducing its therapeutic effect (2✔ ✔Trusted Source
Herb–Drug Interactions with St John’s Wort (Hypericum perforatum): an Update on Clinical Observations
Go to source).
Alprazolam Interactions with Alcohol
Alcohol adds to the effect of alprazolam on the brain or central nervous system (CNS) resulting in excessive drowsiness and decreased motor skills (3✔ ✔Trusted SourceInfluence of ethanol on the metabolism of alprazolam
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When and How to Take Alprazolam
Alprazolam is available only on prescription. It comes in the form of a tablet, extended release tablet, an orally disintegrating tablet (that can dissolve easily in the mouth) and as a concentrated solution (liquid) to be taken orally (by mouth). Follow the instructions exactly as on the label. Do not take more than the prescribed amount. Extended release tablets are usually taken once daily. Others preparations like the tablet, orally disintegrating tablets and concentrated solution are taken two to four times a day (4✔ ✔Trusted SourceAlprazolam: Medlineplus Drug Information
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References
- Effects of repeated ingestion of grapefruit juice on the single and multiple oral-dose pharmacokinetics and pharmacodynamics of alprazolam (https://pubmed.ncbi.nlm.nih.gov/10907671/)
- Herb?Drug Interactions with St John?s Wort (Hypericum perforatum): an Update on Clinical Observations (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2782080/)
- Influence of ethanol on the metabolism of alprazolam (https://pubmed.ncbi.nlm.nih.gov/29848078/)
- Alprazolam: Medlineplus Drug Information (https://medlineplus.gov/druginfo/meds/a684001.html)
