Are you taking Clozapine? Are you aware of the dangers of combining Clozapine with certain foods, herbs or alcohol? Drug-food-interactions are seldom discussed but can lead to undesirable side effects and potentially diminish the efficacy of the medication.
Tobacco smoking and its potential drug interactions.
Go to source).
Cannabis:
National Institute on Alcohol and Alcoholism. (2014) Harmful Interactions: Mixing Alcohol With Medicines.
Go to source).
Yartsev, A., & Peisah, C. (2021). Caffeine-clozapine interaction associated with severe toxicity and multiorgan system failure: a case report. BMC psychiatry, 21(1), 192.
Go to source).
References
1. Ryan, Jessica (2019). Tobacco smoking and its potential drug interactions. https://pharmaceutical-journal.com/article/ld/tobacco-smoking-and-its-potential-drug-interactions
2. Naveed Saleh (2021). 10 prescription drugs that do not mix well with marijuana.https://www.mdlinx.com/article/10-prescription-drugs-that-don-t-mix-well-with-marijuana/1S30QA6pykiTLPdyD33Czu
3. Yartsev, A., & Peisah, C. (2021). Caffeine-clozapine interaction associated with severe toxicity and multiorgan system failure: a case report. BMC psychiatry, 21(1), 192. doi:10.1186/s12888-021-03199-x
4. National Institute on Alcohol and Alcoholism. (2014) Harmful Interactions: Mixing Alcohol With Medicines. https://www.niaaa.nih.gov/publications/brochures-and-fact-sheets/harmful-interactions-mixing-alcohol-with-medicines
5. National Library of Medicine: Clozapine MedlinePlus Drug Information. https://medlineplus.gov/druginfo/meds/a691001.html#
Clozapine Interactions with Food and Herbs
Tobacco: Avoid using tobacco products like cigarettes along with Clozapine as it may induce CYP1A2 and reduce the plasma level and efficacy of the drug (1✔ ✔Trusted SourceTobacco smoking and its potential drug interactions.
Go to source).
Cannabis:
- Avoid using cannabis while taking Clozapine since it reduces its absorption, which can in turn affect its efficacy.
- Concurrent use may increase the risk of depression and other unwanted side effects (2✔ ✔Trusted Source
10 prescription drugs that do not mix well with marijuana
Go to source).
Clozapine Interactions with Alcohol
Consuming alcohol while taking Clozapine can result in adverse effects, including dizziness, drowsiness, depression, and impaired concentration. (4✔ ✔Trusted SourceNational Institute on Alcohol and Alcoholism. (2014) Harmful Interactions: Mixing Alcohol With Medicines.
Go to source).
Clozapine Interactions with Caffeine
Avoid intake of Clozapine along with caffeine-containing products like coffee, tea, cola, and chocolate, as it can inhibit CYP1A2 metabolism and cause unwanted side effects including confusion, dry mouth, headache, drowsiness, dizziness and palpitations (3✔ ✔Trusted SourceYartsev, A., & Peisah, C. (2021). Caffeine-clozapine interaction associated with severe toxicity and multiorgan system failure: a case report. BMC psychiatry, 21(1), 192.
Go to source).
When and How to Take Clozapine
- Clozapine is available in the form of a tablet, an orally disintegrating tablet and an oral suspension (liquid) to take orally (by mouth).
- You may take it preferably once or twice a day with or without food.
- Take the medication at the same time every day for better results.
- Follow the directions exactly as given on the prescription label.
- Stick to the recommended dose and do not skip the prescribed dose of medicine without consulting your doctor (5✔ ✔Trusted Source
National Library of Medicine: Clozapine MedlinePlus Drug Information.
Go to source).
References
1. Ryan, Jessica (2019). Tobacco smoking and its potential drug interactions. https://pharmaceutical-journal.com/article/ld/tobacco-smoking-and-its-potential-drug-interactions
2. Naveed Saleh (2021). 10 prescription drugs that do not mix well with marijuana.https://www.mdlinx.com/article/10-prescription-drugs-that-don-t-mix-well-with-marijuana/1S30QA6pykiTLPdyD33Czu
3. Yartsev, A., & Peisah, C. (2021). Caffeine-clozapine interaction associated with severe toxicity and multiorgan system failure: a case report. BMC psychiatry, 21(1), 192. doi:10.1186/s12888-021-03199-x
4. National Institute on Alcohol and Alcoholism. (2014) Harmful Interactions: Mixing Alcohol With Medicines. https://www.niaaa.nih.gov/publications/brochures-and-fact-sheets/harmful-interactions-mixing-alcohol-with-medicines
5. National Library of Medicine: Clozapine MedlinePlus Drug Information. https://medlineplus.gov/druginfo/meds/a691001.html#
