Are you taking Indomethacin? Are you aware of the dangers of combining Indomethacin with certain foods, herbs, or alcohol? Drug-food-interactions are seldom discussed but can lead to undesirable side effects and potentially diminish the efficacy of the medication.
Feverfew(Tanacetum parthenium is a flowering plant in the daisy family, Asteraceae): Feverfew increases the risk of adverse effects from NSAIDS like gastrointestinal and renal effects.
Gossypol(a polyphenol isolated from roots, stem and leaves of Cotton plants): Avoid gossypol with NSAIDS as it can lead to increased risk of adverse gastrointestinal effects.
Ma huang(Ephedra sinica is a plant species used in traditional Chinese medicine): Ma huang interacts with Indomethacin resulting in increased risk of developing gastric mucosal lesions.
Meadowsweet(Filipendula ulmaria commonly known mead wort, is a perennial herbaceous plant in the family Rosaceae): Avoid intake of meadowsweet while taking NSAIDS, as it can increase the risk of bleeding.
Potassium rich foods: Indomethacin interacts with potassium which may result in hyperkalemia.
Garlic: Garlic interacts with Indomethacin resulting in increased risk of gastrointestinal bleeding(1✔ ✔Trusted Source
Indomethacin: Micromedex Drug Information
Go to source).
Indomethacin: Alcohol/food interaction
Go to source).
References
1. Indomethacin: Micromedex Drug Information
https://www.micromedexsolutions.com/micromedex2/librarian/CS/79E564/ND_PR/evidencexpert/ND_P/evidencexpert/
2. Indomethacin: Alcohol/food interaction
https://www.drugs.com/food-interactions/indomethacin.html
3. Indomethacin: Medlineplus Drug Information
https://medlineplus.gov/druginfo/meds/a681027.html#:~:text=Indomethacin%20is%20used%20to%20relieve,spondylitis%20(arthritis%20that%20mainly%20affects
Indomethacin Interactions with Food and Herbs
Gingko: Ginkgo when taken along with Indomethacin may result in increased risk of GI bleeding.Feverfew(Tanacetum parthenium is a flowering plant in the daisy family, Asteraceae): Feverfew increases the risk of adverse effects from NSAIDS like gastrointestinal and renal effects.
Gossypol(a polyphenol isolated from roots, stem and leaves of Cotton plants): Avoid gossypol with NSAIDS as it can lead to increased risk of adverse gastrointestinal effects.
Ma huang(Ephedra sinica is a plant species used in traditional Chinese medicine): Ma huang interacts with Indomethacin resulting in increased risk of developing gastric mucosal lesions.
Meadowsweet(Filipendula ulmaria commonly known mead wort, is a perennial herbaceous plant in the family Rosaceae): Avoid intake of meadowsweet while taking NSAIDS, as it can increase the risk of bleeding.
Potassium rich foods: Indomethacin interacts with potassium which may result in hyperkalemia.
Garlic: Garlic interacts with Indomethacin resulting in increased risk of gastrointestinal bleeding(1✔ ✔Trusted Source
Indomethacin: Micromedex Drug Information
Go to source).
Indomethacin Interactions with Alcohol
Avoid alcohol intake while taking Indomethacin as it may increase the risk of GI bleeding(2✔ ✔Trusted SourceIndomethacin: Alcohol/food interaction
Go to source).
When and How to Take Indomethacin
- Indomethacin is available in the form of a capsule, an extended release capsule and a suspension to be taken orally with food or with antacids.
- Extended release capsules are usually taken once or twice a day.
- Do not split, chew or crush the extended release capsules.
- Capsule and liquid form of Indomethacin are usually taken two to four times a day.
- Shake the Indomethacin suspension well before use.
- Follow the instructions as directed in the prescription label.
- Do not exceed or miss the dose(3✔ ✔Trusted Source
Indomethacin: Medlineplus Drug Information
Go to source).
References
1. Indomethacin: Micromedex Drug Information
https://www.micromedexsolutions.com/micromedex2/librarian/CS/79E564/ND_PR/evidencexpert/ND_P/evidencexpert/
2. Indomethacin: Alcohol/food interaction
https://www.drugs.com/food-interactions/indomethacin.html
3. Indomethacin: Medlineplus Drug Information
https://medlineplus.gov/druginfo/meds/a681027.html#:~:text=Indomethacin%20is%20used%20to%20relieve,spondylitis%20(arthritis%20that%20mainly%20affects
