Are you taking Larotrectinib? Are you aware of the dangers of combining Larotrectinib with certain foods and herbs? Drug-food-interactions are seldom discussed but can lead to undesirable side effects and potentially diminish the efficacy of the medication.
FDA Approved Drug Products: Vitrakvi Larotrectinib Oral Capsules.
Go to source).
St.John's Wort:This herb stimulates CYP3A metabolism and reduces the serum level of larotrectinib (2✔ ✔Trusted Source
DrugBank Online. Larotrectinib: Uses, Interactions, Mechanism of Action.
Go to source).
References
1. FDA Approved Drug Products: Vitrakvi Larotrectinib Oral Capsules. Retrieved on 8th June 2022 from: https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/210861s000lbl.pdf
2. DrugBank Online. Larotrectinib: Uses, Interactions, Mechanism of Action. Retrieved on 9th June 2022 from: https://go.drugbank.com/drugs/DB14723
3. National Library of Medicine: Larotrectinib MedlinePlus Drug Information. Retrieved on 9th June 2022 from: https://medlineplus.gov/druginfo/meds/a619006.html
Larotrectinib Interactions with Food and Herbs
Grapefruit: Intake of grapefruit juice inhibits CYP3A metabolism that can increase the serum concentration of larotrectinib and cause some side effects including nausea, vomiting, dizziness, cough, and constipation (1✔ ✔Trusted SourceFDA Approved Drug Products: Vitrakvi Larotrectinib Oral Capsules.
Go to source).
St.John's Wort:This herb stimulates CYP3A metabolism and reduces the serum level of larotrectinib (2✔ ✔Trusted Source
DrugBank Online. Larotrectinib: Uses, Interactions, Mechanism of Action.
Go to source).
When and How to Take Larotrectinib
- Larotrectinib is available only on prescription. It comes in the form of capsule and solution (liquid) to take orally (by mouth).
- You will be usually advised to take it twice a day with or without food. Swallow the capsule as a whole instead of crushing, chewing or breaking it.
- Take the medication around the same time every day for better results.
- Follow the instructions as given by your doctor's prescription. Do not stop the use of larotrectinib without consulting your doctor even if you feel good (3✔ ✔Trusted Source
National Library of Medicine: Larotrectinib MedlinePlus Drug Information.
Go to source).
References
1. FDA Approved Drug Products: Vitrakvi Larotrectinib Oral Capsules. Retrieved on 8th June 2022 from: https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/210861s000lbl.pdf
2. DrugBank Online. Larotrectinib: Uses, Interactions, Mechanism of Action. Retrieved on 9th June 2022 from: https://go.drugbank.com/drugs/DB14723
3. National Library of Medicine: Larotrectinib MedlinePlus Drug Information. Retrieved on 9th June 2022 from: https://medlineplus.gov/druginfo/meds/a619006.html
