Are you taking Sirolimus ? Are you aware of the dangers of combining Sirolimus with certain foods and herbs? Drug-food-interactions are seldom discussed but can lead to undesirable side effects and potentially diminish the efficacy of the medication.
Rapamune (sirolimus) tablets label
Go to source).
St. Johns Wort: This herb stimulates CYP3A4 and P-gp, which may lead to a decrease in Sirolimus concentration (1✔ ✔Trusted Source
Rapamune (sirolimus) tablets label
Go to source).
References
1. Rapamune (sirolimus) tablets label https://www.accessdata.fda.gov/drugsatfda_docs/label/2010/021110s058lbl.pdf
2. National Library of Medicine: Sirolimus MedlinePlus Drug Information. https://medlineplus.gov/druginfo/meds/a602026.html#
Sirolimus Interactions with Food and Herbs
Grapefruit: Taking Sirolimus with grapefruit juice reduces CYP3A4-mediated drug metabolism, which can lead to potentially dangerous side effects (1✔ ✔Trusted SourceRapamune (sirolimus) tablets label
Go to source).
St. Johns Wort: This herb stimulates CYP3A4 and P-gp, which may lead to a decrease in Sirolimus concentration (1✔ ✔Trusted Source
Rapamune (sirolimus) tablets label
Go to source).
When and How to Take Sirolimus
- Sirolimus is available in the form of a tablet and a solution (liquid) to be taken orally.
- It is usually taken once a day with or without food.
- Swallow the tablets as a whole instead of crushing, chewing or breaking them.
- Take the medication at the same time every day for better results.
- Follow the directions exactly as given on the prescription label.
- Do not exceed or skip a dose. If you miss it, take the medication as soon as you remember.
- Do not double the dose at a time to compensate for a missed dose (2✔ ✔Trusted Source
National Library of Medicine: Sirolimus MedlinePlus Drug Information.
Go to source).
References
1. Rapamune (sirolimus) tablets label https://www.accessdata.fda.gov/drugsatfda_docs/label/2010/021110s058lbl.pdf
2. National Library of Medicine: Sirolimus MedlinePlus Drug Information. https://medlineplus.gov/druginfo/meds/a602026.html#
