Latest prescription information about Methotrexate. Learn how to pronounce the drug's name, its indications, dosage, how to take, when to take, when not to take, side effects, special precautions, its storage instructions and warnings if any when taken during pregnancy. Also listed are the International and Indian trade name(s) of the drug and its price list. We recommend consulting your doctor to verify the information presented on this page or if you need any further clarifications.
Widely used anticancer drug acting as an antimetabolite in DNA synthesis.
Methotrexate is an antimetabolite that combines with dihydrofolate reductase and interferes with the synthesis of tetrahydrofolicacid (THF) necessary for DNA synthesis.
Normal values depend upon the drug therapy.
>2.27 µg/mL (> 5 µmol/L)
Enzyme immunoassay(EIA), Radio immunoassay(RIA), High performance liquid chromatography (HPLC).
Side effects are mostly dose related and include oral ulcers, hair loss, fatigue, headache, stomach upset, nausea, diarrhea and bone marrow suppression. It can also cause liver and kidney disease, lung disease including fibrosis, skin reactions, infections by organisms like Pneumocystis carinii which do not infect healthy individuals, cancer of the lymph system and birth defects in the unborn child. Combination with salicylate increases incidence of toxicity, due to possible reduced excretion by the kidney.
Drug Name : Methotrexate
Indication :
Widely used anticancer drug acting as an antimetabolite in DNA synthesis.
Physiology :
Methotrexate is an antimetabolite that combines with dihydrofolate reductase and interferes with the synthesis of tetrahydrofolicacid (THF) necessary for DNA synthesis.
Normal Values :
Normal values depend upon the drug therapy.
Critical Values :
>2.27 µg/mL (> 5 µmol/L)
Test Method :
Enzyme immunoassay(EIA), Radio immunoassay(RIA), High performance liquid chromatography (HPLC).
Side effects :
Side effects are mostly dose related and include oral ulcers, hair loss, fatigue, headache, stomach upset, nausea, diarrhea and bone marrow suppression. It can also cause liver and kidney disease, lung disease including fibrosis, skin reactions, infections by organisms like Pneumocystis carinii which do not infect healthy individuals, cancer of the lymph system and birth defects in the unborn child. Combination with salicylate increases incidence of toxicity, due to possible reduced excretion by the kidney.
