Latest prescription information about Phenytoin. Learn how to pronounce the drug's name, its indications, dosage, how to take, when to take, when not to take, side effects, special precautions, its storage instructions and warnings if any when taken during pregnancy. Also listed are the International and Indian trade name(s) of the drug and its price list. We recommend consulting your doctor to verify the information presented on this page or if you need any further clarifications.
Phenytoin is useful drug for partial seizures.
90% of phenytoin is attached to serum proteins. The unbound fraction is active. Primary site of action of phenytoin is motor cortex, where a sodium efflux is formed from the neurons.
10-20 µg/mL (40-79 µmol/L)
Higher than the normal values causes toxicity.
Enzyme Linked Immunosorbent Assay (ELISA), Fluroescence polarization immunoassay.
Adverse effects include uncontrollable eye movements, abnormal body movements, loss of coordination, confusion, slowed thinking, slurred speech, dizziness nausea, vomiting, constipation, unwanted hair growth in girls, coarsening of facial features, acne, enlargement of lips, overgrowth of gums, allergic reactions, megaloblastic anemia (anemia due to reduced folate absorption and increased excretion), osteomalacia (thinning of bone), high blood sugar level, liver damage, and skin reactions. An injection into the vein can cause fall in blood pressure, abnormal heart rhythm or damage to the vessel wall. It should not be used during pregnancy since it can cause fetal anomalies.
Drug Name : Phenytoin
Indication :
Phenytoin is useful drug for partial seizures.
Physiology :
90% of phenytoin is attached to serum proteins. The unbound fraction is active. Primary site of action of phenytoin is motor cortex, where a sodium efflux is formed from the neurons.
Normal Values :
10-20 µg/mL (40-79 µmol/L)
Critical Values :
Higher than the normal values causes toxicity.
Test Method :
Enzyme Linked Immunosorbent Assay (ELISA), Fluroescence polarization immunoassay.
Side effects :
Adverse effects include uncontrollable eye movements, abnormal body movements, loss of coordination, confusion, slowed thinking, slurred speech, dizziness nausea, vomiting, constipation, unwanted hair growth in girls, coarsening of facial features, acne, enlargement of lips, overgrowth of gums, allergic reactions, megaloblastic anemia (anemia due to reduced folate absorption and increased excretion), osteomalacia (thinning of bone), high blood sugar level, liver damage, and skin reactions. An injection into the vein can cause fall in blood pressure, abnormal heart rhythm or damage to the vessel wall. It should not be used during pregnancy since it can cause fetal anomalies.
