It comes as a tablet and an extended-release (long-acting) capsule to take by mouth. The tablet is usually taken twice a day with food.
Angina pectoris- Adult: Initially, 12.5 mg bid increased to 25 mg bid after 2 days.
Heart failure- Adult: Initially, 3.125 mg bid, doubled to 6.25 mg bid after 2 wk if tolerated, then gradually increased to the max dose the patient can tolerate at intervals of not <2 wk. Max dose: >85 kg: 50 mg bid; <85 kg: 25 mg bid.
Left ventricular dysfunction post myocardial infarction- Adult: Initially: 6.25 mg bid, if tolerated, after 3-10 days, increase to 12.5 mg bid and then to a target dose of 25 mg bid.
Dosage & When it is to be taken
Oral- Hypertension- Adult: Initially, 12.5 mg once daily increased to 25 mg once daily after 2 days. Alternatively, initial dose of 6.25 mg bid increased to 12.5 mg bid after 1-2 wk, increased further if necessary to 50 mg once daily or in divided doses. Elderly: 12.5 mg once daily.Angina pectoris- Adult: Initially, 12.5 mg bid increased to 25 mg bid after 2 days.
Heart failure- Adult: Initially, 3.125 mg bid, doubled to 6.25 mg bid after 2 wk if tolerated, then gradually increased to the max dose the patient can tolerate at intervals of not <2 wk. Max dose: >85 kg: 50 mg bid; <85 kg: 25 mg bid.
Left ventricular dysfunction post myocardial infarction- Adult: Initially: 6.25 mg bid, if tolerated, after 3-10 days, increase to 12.5 mg bid and then to a target dose of 25 mg bid.
