Elapegadeaminase-lvlr comes as an injection and should be given by a trained healthcare provider intramuscularly or directly into the muscle.
The injection site can be changed periodically to avoid repeated injury.
Elapegadeaminase-lvlr injection should be inspected for the presence of any visible particles or cloudy solution before injecting and must be discarded if such things are present.
The injection must be removed from the refrigerator and kept outside for at least 30 minutes before injecting by allowing it to come to room temperature.
The injection must be given immediately once withdrawn from the vial and any unused portion left in the vial must be discarded.
I) Patients who are transferred to elapegademase-lvlr from the animal source of ADA (pegademase bovine)-
The recommended initial dose of elapegademase-lvlr is 0.2 mg/kg given once a week if the patient’s weekly dose of pegademase bovine is not known or if it is at or less than 30 U/kg
If the patient’s weekly dose of pegademase bovine is more than 30 U/kg, the exact dose of elapegademase-lvlr can be calculated by the following conversion formula:
Elapegadeaminase-lvlr dose in mg/kg = Pegademase bovine in U/kg divided by 150
The dose of elapegademase-lvlr can be increased gradually by 0.033 mg/kg per week based on the level of ADA and the clinical response of the patient.
II) Patients who have not used pegademase bovine-
The initial dose of elapegademase-lvlr is 0.4 mg/kg per week prescribed based on the body weight which can be given in two doses as 0.2 mg/kg twice a week for a minimum of 12 to 24 weeks.
The dose can be readjusted and the treatment duration is decided based on the ADA enzyme levels and the clinical status of the patient.
• If there is an allergy to elapegademase-lvlr
• With a history of severe thrombocytopenia
Extreme caution is required while treating pregnant women and breastfeeding mothers with elapegademase-lvlr and their status has to be monitored closely.
The injection site can be changed periodically to avoid repeated injury.
Elapegadeaminase-lvlr injection should be inspected for the presence of any visible particles or cloudy solution before injecting and must be discarded if such things are present.
The injection must be removed from the refrigerator and kept outside for at least 30 minutes before injecting by allowing it to come to room temperature.
The injection must be given immediately once withdrawn from the vial and any unused portion left in the vial must be discarded.
Dosage & When it is to be taken
The dose of elapegademase-lvlr is chosen based on the patients who use the animal source of adenosine deaminase and either who do not use or do not have an idea of what medications have been given to them.I) Patients who are transferred to elapegademase-lvlr from the animal source of ADA (pegademase bovine)-
The recommended initial dose of elapegademase-lvlr is 0.2 mg/kg given once a week if the patient’s weekly dose of pegademase bovine is not known or if it is at or less than 30 U/kg
If the patient’s weekly dose of pegademase bovine is more than 30 U/kg, the exact dose of elapegademase-lvlr can be calculated by the following conversion formula:
Elapegadeaminase-lvlr dose in mg/kg = Pegademase bovine in U/kg divided by 150
The dose of elapegademase-lvlr can be increased gradually by 0.033 mg/kg per week based on the level of ADA and the clinical response of the patient.
II) Patients who have not used pegademase bovine-
The initial dose of elapegademase-lvlr is 0.4 mg/kg per week prescribed based on the body weight which can be given in two doses as 0.2 mg/kg twice a week for a minimum of 12 to 24 weeks.
The dose can be readjusted and the treatment duration is decided based on the ADA enzyme levels and the clinical status of the patient.
When it is not to be taken (Contraindications)
Elapegademase-lvlr should not be used in patients-• If there is an allergy to elapegademase-lvlr
• With a history of severe thrombocytopenia
Extreme caution is required while treating pregnant women and breastfeeding mothers with elapegademase-lvlr and their status has to be monitored closely.
