• Ivosidenib comes as a tablet that can be taken by mouth either with or without food.
• Ivosidenib tablets should be taken at the same time each day as prescribed by the doctor.
• Swallow the ivosidenib tablet as a whole with a sufficient quantity of water. Do not crush or split the tablet contents.
• Avoid taking ivosidenib tablets with a high-fat meal as it may increase the availability of ivosidenib which may result in a serious abnormal heart rhythm.
• Never take an extra or another dose if vomiting occurs after taking an ivosidenib tablet but continue with the next scheduled dose.
• If a dose of ivosidenib is missed, administer the missed dose as soon as possible within 12 hours from the missed dose.
• If the next dose is within 12 hours, skip the missed dose and continue with the next dose.
• Taking two doses of ivosidenib tablets within 12 hours is not advised.
• Ivosidenib can be continued for a minimum of 6 months in patients who never show disease progression or when the treatment with drug does not result in intolerable toxicity.
• The dose of ivosidenib can be temporarily stopped or reduced to 250 mg once daily, if abnormal heart rhythm, nerve damage, and symptoms of differentiation syndrome such as an increase in the number of white blood cells occur.
• Treatment with the usual adult dose can be started once the side effects are mild or reduced greatly.
• Similarly, treatment with ivosidenib can be permanently stopped if the symptoms and signs are life-threatening.
• Allergic to ivosidenib
• Pregnancy and breastfeeding
• Guillain-Barré syndrome (Nerve disorder)
• Children under 18 years of age because of the lack of safety and effectiveness data in these age groups
• Undergoing treatment to correct infertility
Caution is required in treating patients with-
• Irregular heartbeat
• Elderly patients
• History of muscle weakness
• Ivosidenib tablets should be taken at the same time each day as prescribed by the doctor.
• Swallow the ivosidenib tablet as a whole with a sufficient quantity of water. Do not crush or split the tablet contents.
• Avoid taking ivosidenib tablets with a high-fat meal as it may increase the availability of ivosidenib which may result in a serious abnormal heart rhythm.
• Never take an extra or another dose if vomiting occurs after taking an ivosidenib tablet but continue with the next scheduled dose.
• If a dose of ivosidenib is missed, administer the missed dose as soon as possible within 12 hours from the missed dose.
• If the next dose is within 12 hours, skip the missed dose and continue with the next dose.
• Taking two doses of ivosidenib tablets within 12 hours is not advised.
Dosage & When it is to be taken
• The recommended dose of ivosidenib tablets is 500 mg taken once daily and continued until the patient shows unacceptable toxicity or progression of the disease.• Ivosidenib can be continued for a minimum of 6 months in patients who never show disease progression or when the treatment with drug does not result in intolerable toxicity.
• The dose of ivosidenib can be temporarily stopped or reduced to 250 mg once daily, if abnormal heart rhythm, nerve damage, and symptoms of differentiation syndrome such as an increase in the number of white blood cells occur.
• Treatment with the usual adult dose can be started once the side effects are mild or reduced greatly.
• Similarly, treatment with ivosidenib can be permanently stopped if the symptoms and signs are life-threatening.
When it is not to be taken (Contraindications)
Ivosidenib should not be used in patients-• Allergic to ivosidenib
• Pregnancy and breastfeeding
• Guillain-Barré syndrome (Nerve disorder)
• Children under 18 years of age because of the lack of safety and effectiveness data in these age groups
• Undergoing treatment to correct infertility
Caution is required in treating patients with-
• Irregular heartbeat
• Elderly patients
• History of muscle weakness
