Discontinue laxative (drug which stimulates bowel) therapy before starting naloxegol.
Alteration in analgesic (painkiller) dosing regimen before starting naloxegol is not required
Naloxegol effect can be seen in patients who have taken opioids for at least 4 weeks
Naloxegol Tablets must be swallowed as whole.
Tablets should not be crushed or chewed.
Discontinue if treatment with the opioid pain medicine is also stopped.
The recommended dose is 1 tablet of 25 mg daily; if not tolerated, reduce to 12.5 mg 1 tablet daily.
In case of severe kidney damage (Creatinine cr. < 60 mL/min), 12.5 mg 1 tablet should be given daily. Slowly the dose can be increased to 25 mg a tablet if tolerated well.
They should be taken on an empty stomach at least 1 hour prior to the first meal of the day or 2 hours after the meal.
• An allergy to naloxegol.
• With a high risk of gastrointestinal obstruction (block in the intestine).
• With any stomach or bowel (intestines) problems, including stomach ulcer, Crohn’s disease, diverticulitis, cancer of the stomach or bowel, or Ogilvie’s syndrome.
• Using medicines like clarithromycin, ketoconazole because they can significantly increase the effect to naloxegol which may increase the opioid withdrawal symptoms such as excess sweating, chills, diarrhoea, abdominal pain, anxiety, irritability, and yawning.
• With kidney problems
• With liver problems
Alteration in analgesic (painkiller) dosing regimen before starting naloxegol is not required
Naloxegol effect can be seen in patients who have taken opioids for at least 4 weeks
Naloxegol Tablets must be swallowed as whole.
Tablets should not be crushed or chewed.
Discontinue if treatment with the opioid pain medicine is also stopped.
The recommended dose is 1 tablet of 25 mg daily; if not tolerated, reduce to 12.5 mg 1 tablet daily.
In case of severe kidney damage (Creatinine cr. < 60 mL/min), 12.5 mg 1 tablet should be given daily. Slowly the dose can be increased to 25 mg a tablet if tolerated well.
Dosage & When it is to be taken
Naloxegol is available as 12.5mg and 25mg tablets for in adults.They should be taken on an empty stomach at least 1 hour prior to the first meal of the day or 2 hours after the meal.
When it is not to be taken (Contraindications)
Naloxegol should not be used in patients:• An allergy to naloxegol.
• With a high risk of gastrointestinal obstruction (block in the intestine).
• With any stomach or bowel (intestines) problems, including stomach ulcer, Crohn’s disease, diverticulitis, cancer of the stomach or bowel, or Ogilvie’s syndrome.
• Using medicines like clarithromycin, ketoconazole because they can significantly increase the effect to naloxegol which may increase the opioid withdrawal symptoms such as excess sweating, chills, diarrhoea, abdominal pain, anxiety, irritability, and yawning.
• With kidney problems
• With liver problems