Talazoparib comes as a capsule to be taken by mouth either with or without food.
Never open or chew the talazoparib capsule but swallow as a whole with a sufficient quantity of water.
For patients with kidney disease, the recommended dose is 0.75 mg once a day.
Talazoparib is also available in 0.25 mg capsule form for the convenience of dose reduction treatment.
The dose of talazoparib can be adjusted based on the severity of the side effects experienced by the patient.
Initially, the dose can be reduced to 0.75 mg (three 0.25 mg capsules) once daily if any intolerable side effects occur followed by 0.5 mg (two 0.25 mg capsules) once daily if further dose reductions are necessary.
Talazoparib dose can be again reduced to 0.25 mg once a day if the side effects are severe. The treatment can be discontinued permanently if further dose reductions are required.
Treatment with talazoparib must be continued in patients who never show any disease progression or when the treatment with the drug does not result in intolerable toxicity.
• If there is an allergy to talazoparib
• Pregnant or breastfeeding women
• Males who undergo treatment to correct infertility
Talazoparib should not be used in children below 18 years of age as the safety and the effectiveness of talazoparib were not tested in these age groups.
Extreme caution is required while giving talazoparib to patients with moderate to severe liver damage or kidney disease.
The next capsule should be taken at its usual prescribed time probably the next day as per the schedule.
Never open or chew the talazoparib capsule but swallow as a whole with a sufficient quantity of water.
Dosage & When it is to be taken
The recommended dose of talazoparib is 1mg taken once a day.For patients with kidney disease, the recommended dose is 0.75 mg once a day.
Talazoparib is also available in 0.25 mg capsule form for the convenience of dose reduction treatment.
The dose of talazoparib can be adjusted based on the severity of the side effects experienced by the patient.
Initially, the dose can be reduced to 0.75 mg (three 0.25 mg capsules) once daily if any intolerable side effects occur followed by 0.5 mg (two 0.25 mg capsules) once daily if further dose reductions are necessary.
Talazoparib dose can be again reduced to 0.25 mg once a day if the side effects are severe. The treatment can be discontinued permanently if further dose reductions are required.
Treatment with talazoparib must be continued in patients who never show any disease progression or when the treatment with the drug does not result in intolerable toxicity.
When it is not to be taken (Contraindications)
Talazoparib should not be used in patients-• If there is an allergy to talazoparib
• Pregnant or breastfeeding women
• Males who undergo treatment to correct infertility
Talazoparib should not be used in children below 18 years of age as the safety and the effectiveness of talazoparib were not tested in these age groups.
Extreme caution is required while giving talazoparib to patients with moderate to severe liver damage or kidney disease.
What if you Miss a Dose of Talazoparib?
If the patient either vomits or misses a dose of talazoparib, do not take one more capsule or additional dose.The next capsule should be taken at its usual prescribed time probably the next day as per the schedule.
