Tegafur-uracil is available in a capsule form which should be taken by mouth at least 1 hour before or 1 hour after food three times daily for 28 days.
Do not take tegafur-uracil capsules for more than 28 days.
Never open, crush, break or chew the capsules of tegafur-uracil but swallow as a whole with sufficient quantity of water.
Calcium folinate capsules should be taken at the same time as the tegafur-uracil capsules.
If vomiting occurs after taking tegafur-uracil capsules, do not repeat the dose but continue with the next dose.
The recommended daily dose of tegafur is 300 mg/m2 and uracil is 672 mg/m2 along with oral calcium folinate as 90mg (30 mg/dose) given three times daily (every 8 hours) for 28 days continuously followed by a 7-day treatment-free period.
If the dose amount of tegafur and uracil combination cannot be divided equally the highest dose can be taken in the morning followed by a low dose in the afternoon and the evening.
The doses of tegafur and uracil can be reduced if any blood-related or other types of toxicities occur during the treatment.
In case of severe side effects, the dose of tegafur-uracil can be reduced.
• If there is an allergy to tegafur and uracil
• Pregnancy and breastfeeding
• Children below 18 years of age
• Undergoing treatments to correct infertility
Caution is required if tegafur and uracil is used in the following patients with-
• Severe kidney disease
• History of liver dysfunction
• Heart-related illnesses
• Symptoms of bowel obstruction
• Dihydropyrimidine dehydrogenase deficiency
• Elderly patients
Never take a double dose of tegafur and uracil capsules to make up for the missed dose, and do not take the missed dose at the end of the treatment cycle which can be harmful.
Do not take tegafur-uracil capsules for more than 28 days.
Never open, crush, break or chew the capsules of tegafur-uracil but swallow as a whole with sufficient quantity of water.
Calcium folinate capsules should be taken at the same time as the tegafur-uracil capsules.
If vomiting occurs after taking tegafur-uracil capsules, do not repeat the dose but continue with the next dose.
Dosage & When it is to be taken
The doses of tegafur and uracil are calculated based on the body surface area taking into account the individual patient’s height and weight and given repeatedly for 35 days (1 treatment cycle).The recommended daily dose of tegafur is 300 mg/m2 and uracil is 672 mg/m2 along with oral calcium folinate as 90mg (30 mg/dose) given three times daily (every 8 hours) for 28 days continuously followed by a 7-day treatment-free period.
If the dose amount of tegafur and uracil combination cannot be divided equally the highest dose can be taken in the morning followed by a low dose in the afternoon and the evening.
The doses of tegafur and uracil can be reduced if any blood-related or other types of toxicities occur during the treatment.
In case of severe side effects, the dose of tegafur-uracil can be reduced.
When it is not to be taken (Contraindications)
Tegafur and uracil combination drugs should not be used in patients-• If there is an allergy to tegafur and uracil
• Pregnancy and breastfeeding
• Children below 18 years of age
• Undergoing treatments to correct infertility
Caution is required if tegafur and uracil is used in the following patients with-
• Severe kidney disease
• History of liver dysfunction
• Heart-related illnesses
• Symptoms of bowel obstruction
• Dihydropyrimidine dehydrogenase deficiency
• Elderly patients
What if you Miss a Dose of Tegafur and Uracil?
If a dose of tegafur and uracil is missed do not take the missed dose but continue with the following dose.Never take a double dose of tegafur and uracil capsules to make up for the missed dose, and do not take the missed dose at the end of the treatment cycle which can be harmful.
