Review the side-effects of Methotrexate as documented in medical literature. The term "side effects" refers to unintended effects that can occur as a result of taking the medication. In majority of the instances these side-effects are mild and easily tolerable, however sometimes they can be more severe and can be detrimental.
If the side effects are not tolerable adjusting the dosage or switching to a different medication can help to manage or overcome side effects. If you have any doubts or questions, we recommend seeking advice from your doctor or pharmacist.
Central Nervous System- Dizziness, fatigue, headache, language disorder, weakness, paresis, convulsions, destruction of the myelin sheaths (IV after cranio spinal irradiation), inflammation of the arachnoid (a covering of the brain), transient paresis, nerve damage.
Skin- Redness of the skin, rashes, itching, loss of hair, hives, photosensitivity, pigmentary changes, skin discoloration, dilatation of blood vessels, acne, furunculosis, aggravation of psoriasis by ultraviolet light, severe allergic reactions.
Eye and ENT- Blurred vision, inflammation of the gums, inflammation of pharynx.
Gastrointestinal- Nausea, vomiting, enteritis, mouth ulcer, diarrhea, abdominal distress (common), loss of appetite, blood in vomit, blood in stool, GI ulceration and bleeding.
Genitourinary- Renal failure, blood contains excess amount nitrogen, inflammation of the urinary bladder, blood in urine, severe kidney disease, reproductive disorders, infertility, abortion, fetal defects.
Blood- Deficiency of all three blood cell types, bone marrow depression, anemia, bleeding, presence of bacteria in the blood (septicemia).
Liver- Elevated LFTs (liver function test), liver damage.
Respiratory- Deaths from interstitial pneumonia, chronic interstitial obstructive lung disease.
Miscellaneous- Malaise, chills, fever, lower resistance to infections, joint pain, muscle pain, diabetes, osteoporosis, allergic reactions, sudden death.
If the side effects are not tolerable adjusting the dosage or switching to a different medication can help to manage or overcome side effects. If you have any doubts or questions, we recommend seeking advice from your doctor or pharmacist.
Central Nervous System- Dizziness, fatigue, headache, language disorder, weakness, paresis, convulsions, destruction of the myelin sheaths (IV after cranio spinal irradiation), inflammation of the arachnoid (a covering of the brain), transient paresis, nerve damage.
Skin- Redness of the skin, rashes, itching, loss of hair, hives, photosensitivity, pigmentary changes, skin discoloration, dilatation of blood vessels, acne, furunculosis, aggravation of psoriasis by ultraviolet light, severe allergic reactions.
Eye and ENT- Blurred vision, inflammation of the gums, inflammation of pharynx.
Gastrointestinal- Nausea, vomiting, enteritis, mouth ulcer, diarrhea, abdominal distress (common), loss of appetite, blood in vomit, blood in stool, GI ulceration and bleeding.
Genitourinary- Renal failure, blood contains excess amount nitrogen, inflammation of the urinary bladder, blood in urine, severe kidney disease, reproductive disorders, infertility, abortion, fetal defects.
Blood- Deficiency of all three blood cell types, bone marrow depression, anemia, bleeding, presence of bacteria in the blood (septicemia).
Liver- Elevated LFTs (liver function test), liver damage.
Respiratory- Deaths from interstitial pneumonia, chronic interstitial obstructive lung disease.
Miscellaneous- Malaise, chills, fever, lower resistance to infections, joint pain, muscle pain, diabetes, osteoporosis, allergic reactions, sudden death.
