Side effect(s) of Patisiran

Review the side-effects of Patisiran as documented in medical literature. The term "side effects" refers to unintended effects that can occur as a result of taking the medication. In majority of the instances these side-effects are mild and easily tolerable, however sometimes they can be more severe and can be detrimental.

If the side effects are not tolerable adjusting the dosage or switching to a different medication can help to manage or overcome side effects. If you have any doubts or questions, we recommend seeking advice from your doctor or pharmacist.

  Infusion-related reactions: Skin redness, pain, and swelling at the injection site, stomach pain, headache, fluctuations in blood pressure, nausea, swelling of the face and lips

  Respiratory: Pharyngitis, sinusitis, rhinitis, nasal congestion, bronchitis, lung infections, breathing difficulty

  Musculoskeletal: Muscle pain, back pain, pain in the joints

  Others: Indigestion, vertigo, vision disturbances, dry eye

Other Precautions :

• Inspect the patisiran vial for the presence of any visible particles or discoloration before diluting and administering to the patient. Discard the vial or the diluted mixture if such conditions exist.

• The vial should be removed from the freezer and allowed to cool down to room temperature before diluting it into an infusion bag.

• Do not shake but gently invert the infusion bag to facilitate mixing.