Review the side-effects of Pexidartinib as documented in medical literature. The term "side effects" refers to unintended effects that can occur as a result of taking the medication. In majority of the instances these side-effects are mild and easily tolerable, however sometimes they can be more severe and can be detrimental.
If the side effects are not tolerable adjusting the dosage or switching to a different medication can help to manage or overcome side effects. If you have any doubts or questions, we recommend seeking advice from your doctor or pharmacist. Elevated liver enzymes, change in hair color, fatigue,
Increased cholesterol
Decreased neutrophils, lymphocytes, hemoglobin
Rash
Impaired sense of taste, and decreased phosphate.
• Pexidartinib can cause serious liver injury. Monitor liver function test before starting Pexidartinib and during the treatment at specified intervals. In case of severe liver toxicity, stop or reduce dose of Pexidartinib.
• During treatment with Pexidartinib, inform your healthcare provider immediately if you develop any symptoms of liver disease like- loss of appetite, vomiting, abdominal pain, fever, rash, itching, nausea, tenderness, fatigue.
• Stop taking Pexidartinib and inform your healthcare provider if you develop symptoms like yellowing of skin, eyes and dark urine.
• Pexidartinib is available through a restricted program because of its risk of hepatotoxicity.
• Embryo-fetal toxicity- Pexidartinib can cause fetal harm when administered to pregnant women.
• Females should use effective contraception during treatment and 1 month after the final dose.
• Advise males with female partners of reproductive potential to use effective contraception during treatment and 1 week after the final dose.
• Do not take Proton pump inhibitors (Pantoprazole, omeprazole, rabeprazole, lansoprazole), St John Worts and grapefruit juice along with Pexidartinib.
• Inform your healthcare provider about all the prescription medicines, vitamins, OTC products and herbal medicines.
If the side effects are not tolerable adjusting the dosage or switching to a different medication can help to manage or overcome side effects. If you have any doubts or questions, we recommend seeking advice from your doctor or pharmacist. Elevated liver enzymes, change in hair color, fatigue,
Increased cholesterol
Decreased neutrophils, lymphocytes, hemoglobin
Rash
Impaired sense of taste, and decreased phosphate.
Other Precautions :
• Before taking Pexidartinib, inform your healthcare provider if you are suffering from liver diseases.• Pexidartinib can cause serious liver injury. Monitor liver function test before starting Pexidartinib and during the treatment at specified intervals. In case of severe liver toxicity, stop or reduce dose of Pexidartinib.
• During treatment with Pexidartinib, inform your healthcare provider immediately if you develop any symptoms of liver disease like- loss of appetite, vomiting, abdominal pain, fever, rash, itching, nausea, tenderness, fatigue.
• Stop taking Pexidartinib and inform your healthcare provider if you develop symptoms like yellowing of skin, eyes and dark urine.
• Pexidartinib is available through a restricted program because of its risk of hepatotoxicity.
• Embryo-fetal toxicity- Pexidartinib can cause fetal harm when administered to pregnant women.
• Females should use effective contraception during treatment and 1 month after the final dose.
• Advise males with female partners of reproductive potential to use effective contraception during treatment and 1 week after the final dose.
• Do not take Proton pump inhibitors (Pantoprazole, omeprazole, rabeprazole, lansoprazole), St John Worts and grapefruit juice along with Pexidartinib.
• Inform your healthcare provider about all the prescription medicines, vitamins, OTC products and herbal medicines.
