Review the side-effects of Selinexor as documented in medical literature. The term "side effects" refers to unintended effects that can occur as a result of taking the medication. In majority of the instances these side-effects are mild and easily tolerable, however sometimes they can be more severe and can be detrimental.
If the side effects are not tolerable adjusting the dosage or switching to a different medication can help to manage or overcome side effects. If you have any doubts or questions, we recommend seeking advice from your doctor or pharmacist. Side effects include thrombocytopenia(low platelet count), tiredness, nausea, anemia, decreased appetite, decreased weight, diarrhea, vomiting, low sodium levels, low white blood cell count, constipation, dyspnea, and upper respiratory tract infection
• Gastrointestinal symptoms like nausea, vomiting, weight loss, anorexia, and diarrhea can occur hence, antiemetics like aprepitant, dolasetron, ondansetron should be given before each dose. The dose should be stopped or adjusted according to the symptoms.
• Decreased sodium levels can occur during therapy hence, sodium levels should be monitored. Hyperglycemia and high serum paraprotein levels should be corrected.
• Signs and symptoms of infections should be monitored and treated.
• Do not take Selinexor with other medications likesilodosin, scopolamine, benazepril, antiepileptic drugs that can dizziness or confusion.
• Do not operate heavy machinery after taking Selinexor. To avoid dizziness or confusion, optimize hydration status, blood count and concomitant medications.
• Selinexor can cause fetal harm. Hence, females of reproductive potential should use effective contraception. Males with female partners who can get pregnant should use effective contraception.
• During treatment with Selinexor, inform your healthcare provider if bruising or bleeding occurs.
• Before taking Selinexor inform your healthcare provider about recent infections and bleeding problems.
• Patients should inform their doctors about all the medications they take including herbal medications, OTC products, and vitamin supplements.
If the side effects are not tolerable adjusting the dosage or switching to a different medication can help to manage or overcome side effects. If you have any doubts or questions, we recommend seeking advice from your doctor or pharmacist. Side effects include thrombocytopenia(low platelet count), tiredness, nausea, anemia, decreased appetite, decreased weight, diarrhea, vomiting, low sodium levels, low white blood cell count, constipation, dyspnea, and upper respiratory tract infection
Other Precautions :
• Monitor platelet count and neutrophil count before and during treatment with Selinexor. The dose should be stopped or adjusted accordingly.• Gastrointestinal symptoms like nausea, vomiting, weight loss, anorexia, and diarrhea can occur hence, antiemetics like aprepitant, dolasetron, ondansetron should be given before each dose. The dose should be stopped or adjusted according to the symptoms.
• Decreased sodium levels can occur during therapy hence, sodium levels should be monitored. Hyperglycemia and high serum paraprotein levels should be corrected.
• Signs and symptoms of infections should be monitored and treated.
• Do not take Selinexor with other medications likesilodosin, scopolamine, benazepril, antiepileptic drugs that can dizziness or confusion.
• Do not operate heavy machinery after taking Selinexor. To avoid dizziness or confusion, optimize hydration status, blood count and concomitant medications.
• Selinexor can cause fetal harm. Hence, females of reproductive potential should use effective contraception. Males with female partners who can get pregnant should use effective contraception.
• During treatment with Selinexor, inform your healthcare provider if bruising or bleeding occurs.
• Before taking Selinexor inform your healthcare provider about recent infections and bleeding problems.
• Patients should inform their doctors about all the medications they take including herbal medications, OTC products, and vitamin supplements.
