Review the side-effects of Siponimod as documented in medical literature. The term "side effects" refers to unintended effects that can occur as a result of taking the medication. In majority of the instances these side-effects are mild and easily tolerable, however sometimes they can be more severe and can be detrimental.
If the side effects are not tolerable adjusting the dosage or switching to a different medication can help to manage or overcome side effects. If you have any doubts or questions, we recommend seeking advice from your doctor or pharmacist. o General: Headache, Infections, Decreased immunity
o Eye: Macular swelling
o Heart: Low heart rate, conduction abnormalities
o Gastrointestinal: Liver injury (raised liver enzymes)
o Vascular: Increased blood pressure
o Respiratory: Decreased lung capacity.
2. Eye evaluation is recommended before starting treatment as there is an increased chance of macular swelling
3. Siponimod may lower heart rate. So, get cardiologist consultation before concomitant use with other drugs that decrease heart rate.
4. Siponimod may cause a decline in lung function. So, assess pulmonary function before starting the drug.
5. Check liver enzymes before initiation of drug.
6. Monitor BP frequently during treatment.
7. Women of childbearing potential should use effective contraception during and for 10 days after stopping Siponimod.
If the side effects are not tolerable adjusting the dosage or switching to a different medication can help to manage or overcome side effects. If you have any doubts or questions, we recommend seeking advice from your doctor or pharmacist. o General: Headache, Infections, Decreased immunity
o Eye: Macular swelling
o Heart: Low heart rate, conduction abnormalities
o Gastrointestinal: Liver injury (raised liver enzymes)
o Vascular: Increased blood pressure
o Respiratory: Decreased lung capacity.
Other Precautions :
1. Siponimod may increase the chance of infections. So, obtain a complete blood count (CBC) before initiating treatment.2. Eye evaluation is recommended before starting treatment as there is an increased chance of macular swelling
3. Siponimod may lower heart rate. So, get cardiologist consultation before concomitant use with other drugs that decrease heart rate.
4. Siponimod may cause a decline in lung function. So, assess pulmonary function before starting the drug.
5. Check liver enzymes before initiation of drug.
6. Monitor BP frequently during treatment.
7. Women of childbearing potential should use effective contraception during and for 10 days after stopping Siponimod.
