Review the side-effects of Trastuzumab with Hyaluronidase as documented in medical literature. The term "side effects" refers to unintended effects that can occur as a result of taking the medication. In majority of the instances these side-effects are mild and easily tolerable, however sometimes they can be more severe and can be detrimental.
If the side effects are not tolerable adjusting the dosage or switching to a different medication can help to manage or overcome side effects. If you have any doubts or questions, we recommend seeking advice from your doctor or pharmacist. • General: Fatigue, Injection site reaction, headache, fever, chills, infection
• Musculoskeletal: Joint pain, muscle pain
• GI: Diarrhea
• Respiratory: Upper respiratory tract infection, cough
• Nervous system: Insomnia (lack of sleep)
• The drug can cause pulmonary toxicity in the form of anaphylaxis (allergic reaction), angioedema (swelling under the skin), and acute respiratory distress syndrome (accumulation of fluid in lungs, symptom- shortness of breath).
• If taken during pregnancy, Trastuzumab can cause oligohydramnios (volume of amniotic fluid is low), and neonatal death. Effective contraception must be used during treatment and 7 months after the last dose is given.
• Trastuzumab can exacerbate chemotherapy-induced low white cell count.
• Monitor patients for reactions like skin rash, shortness of breath, nausea, dizziness, low blood pressure.
If the side effects are not tolerable adjusting the dosage or switching to a different medication can help to manage or overcome side effects. If you have any doubts or questions, we recommend seeking advice from your doctor or pharmacist. • General: Fatigue, Injection site reaction, headache, fever, chills, infection
• Musculoskeletal: Joint pain, muscle pain
• GI: Diarrhea
• Respiratory: Upper respiratory tract infection, cough
• Nervous system: Insomnia (lack of sleep)
Other Precautions :
• The drug can cause heart failure. Monitor cardiac function before and during treatment.• The drug can cause pulmonary toxicity in the form of anaphylaxis (allergic reaction), angioedema (swelling under the skin), and acute respiratory distress syndrome (accumulation of fluid in lungs, symptom- shortness of breath).
• If taken during pregnancy, Trastuzumab can cause oligohydramnios (volume of amniotic fluid is low), and neonatal death. Effective contraception must be used during treatment and 7 months after the last dose is given.
• Trastuzumab can exacerbate chemotherapy-induced low white cell count.
• Monitor patients for reactions like skin rash, shortness of breath, nausea, dizziness, low blood pressure.
