| Use: |
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Treatment of endometriosis, fibrocystic breast disease, and hereditary angioedema |
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| Pregnancy & Lactation : |
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Risk Factor - X |
|
| Warnings & Precautions: |
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Use with caution in patients with seizure disorders, migraine, or conditions influenced by edema; impaired hepatic, renal, or cardiac disease, pregnancy, lactation
|
|
| Contraindication: |
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Undiagnosed genital bleeding, hypersensitivity to danazol or any component; pregnancy | |
| Adverse Reactions : |
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>10% : Cardiovascular: Edema ; Dermatologic: Oily skin, acne, hirsutism ; Endocrine & metabolic: Fluid retention, breakthrough bleeding, irregular menstrual periods, decreased breast size; Gastrointestinal: Weight gain; Hepatic: Hepatic impairment ; Miscellaneous: Voice deepening ; |
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1% to 10% : Endocrine & metabolic: Virilization, androgenic effects, amenorrhea, hypoestrogenism ; Neuromuscular & skeletal: Weakness ;<1% : Benign intracranial hypertension, dizziness, headache, skin rashes, photosensitivity, pancreatitis, bleeding gums, monilial vaginitis, testicular atrophy, enlarged clitoris, cholestatic jaundice, carpal tunnel syndrome | |
Over Dose / Poisoning : |
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Increased toxicity: Decreased insulin requirements; warfarin may increase anticoagulant effects
| |
Dosage : |
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Adults: Oral:
Endometriosis: 100-400 mg twice daily for 3-6 months (may extend to 9 months)
Fibrocystic breast disease: 50-200 mg twice daily for 2-6 months
Hereditary angioedema: 400-600 mg/day in 2-3 divided doses |
Patient Information : |
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Notify physician if masculinity effects occur; virilization may occur in female patients; report menstrual irregularities; male patients report persistent penile erections; all patients should report persistent GI distress, diarrhea, or jaundice | | |
Comments
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