Dental: Treatment of anxiety, as a preoperative sedative in pediatric dentistry .
Medical: Treatment of anxiety, as a preoperative sedative, an antipruritic, an antiemetic, and in alcohol withdrawal symptoms

S.C., intra-arterial and I.V. administration not recommended since thrombosis and digital gangrene can occur; extravasation can result in sterile abscess and marked tissue induration; should be used with caution in patients with narrow-angle glaucoma, prostatic hypertrophy, and bladder neck obstruction;

should also be used with caution in patients with asthma or COPD Anticholinergic effects are not well tolerated in the elderly. Hydroxyzine may be useful as a short-term antipruritic, but it is not recommended for use as a sedative or anxiolytic in the elderly.

Hypersensitivity to hydroxyzine or any component

>10%: Central nervous system: Slight to moderate drowsiness Respiratory: Thickening of bronchial secretions
1% to 10%: Central nervous system: Headache, fatigue, nervousness, dizziness Gastrointestinal: Appetite increase, weight gain, nausea, diarrhea, abdominal pain, xerostomia Neuromuscular & skeletal: Arthralgia Respiratory: Pharyngitis

Decreased effect: Epinephrine decreased vasopressor effect
Increased toxicity: CNS depressants, anticholinergics

Over Dose / Poisoning : Symptoms of overdose include seizures, sedation, hypotension. There is no specific treatment for an antihistamine overdose, however, most of its clinical toxicity is due to anticholinergic effects. Anticholinesterase inhibitors may be useful by reducing acetylcholinesterase.

For anticholinergic overdose with severe life-threatening symptoms, physostigmine 1-2 mg (0.5 mg or 0.02 mg/kg for children) I.V., slowly may be given to reverse these effects.

Children: Oral: 0.6 mg/kg/dose every 6 hours. I.M.: 0.5-1 mg/kg/dose every 4-6 hours as needed
Adults: Antiemetic: I.M.: 25-100 mg/dose every 4-6 hours as needed

Anxiety: Oral: 25-100 mg 4 times/day; maximum dose: 600 mg/day
Preoperative sedation: Oral: 50-100 mg I.M.: 25-100 mg
Management of pruritus: Oral: 25 mg 3-4 times/day
Dosing interval in hepatic impairment: Change dosing interval to every 24 hours in patients with primary biliary cirrhosis

Take this drug as prescribed; do not increase dosage or discontinue without consulting prescriber. Store medication away from light. Maintain adequate hydration (2-3 L/day of fluids unless instructed to restrict fluid intake). Void before taking medication. Do not use excessive alcohol or other CNS

depressants or sleeping aids without consulting prescriber. May cause dizziness, drowsiness, or blurred vision (use caution when driving or engaging in tasks requiring alertness until response to drug is known); or nausea, dry mouth, appetite disturbances (small frequent meals, frequent mouth care, or sucking hard candy may help). Report unusual weight gain, unresolved nausea or diarrhea, chest pain or palpitations, muscle or joint pain, excess sedation, sore throat, or difficulty breathing. Pregnancy/breast-feeding precautions: Inform prescriber if you are or intend to be pregnant. Consult prescriber if breast-feeding.