Prevention and treatment of infection in second and third degree burns

Use with caution in patients with G-6-PD deficiency, renal impairment, or history of allergy to other sulfonamides; sulfadiazine may accumulate in patients with impaired hepatic or renal function; fungal superinfection may occur; use of analgesic might be needed before application; systemic absorption is significant and adverse reactions may occur

Hypersensitivity to silver sulfadiazine or any component; premature infants or neonates <2 months of age because sulfonamides compete with bilirubin for protein binding sites which may displace bilirubin and cause kernicterus, pregnant women approaching or at term

1% to 10%: Dermatologic: Itching, rash, erythema multiforme, discoloration of skin Hematologic: Hemolytic anemia, leukopenia, agranulocytosis, aplastic anemia Hepatic: Hepatitis Renal: Interstitial nephritis Miscellaneous: Allergic reactions may be related to sulfa component <1%: Photosensitivity

Decreased effect: Topical proteolytic enzymes are inactivated

Children and Adults: Topical: Apply once or twice daily with a sterile-gloved hand; apply to a thickness of 1/16"; burned area should be covered with cream at all times

Usually applied by professional in burn care setting. Patient instruction should be appropriate to extent of burn, patient understanding, etc.