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Biology Of Tissue Response To Disease

Inflammation, including cells and mediators

  • Acute inflammation and mediator systems
  • Vascular response to injury, including mediators
  • Inflammatory

    cell recruitment, including adherence and cell migration, and phagocytosis
  • Bactericidal mechanisms and tissue injury
  • Clinical manifestations (eg, pain, fever, leukocytosis, leukemoid reaction, and chills)
  • Chronic inflammation

Reparative processes

  • Wound healing, hemostasis, and repair: thrombosis, granulation tissue, angiogenesis, fibrosis, scar/keloid formation
  • Regenerative processes

Neoplasia

  • Classification,
    histologic diagnosis
  • Grading and staging of neoplasms
  • Cell biology, biochemistry, and molecular biology of neoplastic cells: transformation, oncogenes, altered cell differentiation, and proliferation
  • Hereditary neoplastic disorders
  • Invasion and metastasis
  • Tumor immunology
  • Paraneoplastic manifestations of cancer
  • Cancer epidemiology and prevention
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