Immune Responses

Alterations in immunologic function

• T- or B-lymphocyte deficiencies (eg, DiGeorge Syndrome)
• Deficiencies of phagocytic cells
• Combined immunodeficiency disease
• HIV
  
  infection/AIDS and other acquired disorders of immune responsiveness
• Drug-induced alterations in immune responses, immunopharmacology

Immunologically mediated disorders

• Hypersensitivity (types I-IV)
• Transplant rejection
• Autoimmune disorders
• Risks of transplantation, transfusion (eg, graft-versus-host disease)
• Isoimmunization, hemolytic disease of the newborn Immunopathogenesis

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