Global Markets for Media, Sera and Reagents in Biotechnology -- Focus on the U.S.
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INTRODUCTION
STUDY OBJECTIVES
BCC's goal in conducting this study is to provide an overview of the current and future characteristics of the global market for media, sera and the reagents used in biotechnology. The key objective is to present a comprehensive analysis of the current market and its future direction in the media, sera and biotechnology reagents markets as an important tool for the cell culture industry.
This report explores present and future strategies within the media and sera market, including reagents used in biotechnology. The improvisation of the market, the setbacks and the needs of the market are discussed in this report. The types of cell cultures and the products from cell culture technology are also presented in this report. The advantages and disadvantages for the use of various types of media are also covered in this report.
A detailed analysis of the cell culture industry structure has been conducted. This includes the biotechnology reagents, media and the sera used. Revenues are broken down by global region. Sales figures are estimated for the five-year period from 2011 through 2016.
Applications for the cell culture industry—media, sera and reagents used in biotechnology—are also discussed in the report, with an emphasis on the usage in the research, production and contract segments. The report also covers significant patents in each segment.
REASONS FOR DOING THIS STUDY
Demand for cell culture products, namely media, sera and reagents, is increasing, with the increasing demand for biopharmaceuticals. Cell culture, a crucial component of the life sciences industry, has witnessed major development during the past three decades. R&D spending, along with increasing competition, patent expiries, new technologies and an international marketplace are moving the cell culture process in a new direction. As cell culture technologies evolved, a number of disciplines such as cell biology, genetic engineering, protein chemistry, genomics and chemical engineering have been successfully incorporated into the cell culture field.
Acquisition strategies and collaborations by companies are also covered in this report. This study also discusses the strength and weaknesses of the different types of media used in light of the new technologies, growing competition and changing customer needs.
INTENDED AUDIENCE
This study contributes to the areas of market growth in the cell culture industry from the point of view of manufacturers and users. Biotechnological companies, physicians, the pharmaceutical and biopharmaceutical industries, hospitals and research institutes will find this study to be of interest.
SCOPE OF THE STUDY
The scope of this study encompasses the biotechnology, pharmaceutical and medical markets. BCC analyzes each market and its applications by its need for development of new medications through cell culture techniques, the regulatory environment, technology involved, market projections and market share. Technological issues include the latest trends and developments.
METHODOLOGY
BCC conducted a comprehensive literature search, which included technical newsletters and journals, and many other sources. Data was collected through interviews and correspondence with various analytical, chemical, pharmaceutical and biotechnical experts. Projections were based on estimates such as the current number of end users, potential end users, mergers and acquisitions, and market trends.
INFORMATION SOURCES
Many companies within the industry were surveyed to obtain data for this study. Included were manufacturers and end users of biopharmaceuticals, and pharmaceutical companies through their production, research and contract manufacturing/research lines. Data were gathered from various industry sources. BCC spoke with officials and physicians within the industry, consulted newsletters, company literature, product literature and a host of technical articles, journals, indexes and abstracts. Exhaustive investigations of databases by key terminology were completed. In addition, data were compiled from current financial, trade and government sources.
ABOUT THE AUTHOR
The study has been carried out by a team of professionals in the biotechnology industry. The project manager for this project is Shalini S. Dewan, who holds a Master's degree in Pharmaceutical Chemistry and has more than 14 years of industry experience. Among the research topics she has covered are studies on compounds of potential pharmaceutical interest from ibuprofen and 2-naphthyl acetic acid. Shalini was awarded a Gold Medal by the Prime Minister of India for her work and has worked with top companies in India and in the U.S. Some of her other reports with BCC are Reagents for Chromatography; Spectroscopy, an Enduring Market; Advanced Drug Delivery Systems: Technologies and Global Markets; Orthopedic Drugs, Implants and Devices; Medical Imaging Reagents and Analysis Equipment; Pharmaceutical Regulatory Industry; The Dynamic Media, Sera and Reagent Market in Biotechnology; Contract Pharmaceutical Manufacturing, Research and Packaging: Global Markets; Chiral Technology: Global Markets; Autacoids and Related Drugs: Technologies and Global Markets; Contraceptives: Technologies and Global Markets; Liver Disease Treatments: The Global Market; Hormone Replacement Therapies and Other Hormone Therapies: Global Markets; Cardiovascular Medicine: Diagnostics, Drugs and Devices; and Cancer Therapies: Technologies and Global Markets.
The lead consultant for this project was Dr. Kapil A. Setia, who holds a doctoral degree in the life sciences. She has a number of research publications to her credit.
TABLE OF CONTENTS
CHAPTER ONE: INTRODUCTION 1
STUDY OBJECTIVES 1
REASONS FOR DOING THIS STUDY 1
INTENDED AUDIENCE 2
SCOPE OF THE STUDY 2
METHODOLOGY 2
INFORMATION SOURCES 2
ABOUT THE AUTHOR 3
RELATED BCC RESEARCH REPORTS 3
BCC ONLINE SERVICES 3
DISCLAIMER 4
CHAPTER TWO: EXECUTIVE SUMMARY 5
EXECUTIVE SUMMARY 5
SUMMARY TABLE GLOBAL REVENUES FROM MEDIA, SERA AND
REAGENTS USED IN THE BIOTECHNOLOGY MARKET,
THROUGH 2016 ($ MILLIONS) 6
SUMMARY FIGURE GLOBAL REVENUES FROM MEDIA, SERA AND
REAGENTS USED IN THE BIOTECHNOLOGY MARKET, 2009-2016
($ MILLIONS) 6
EXECUTIVE SUMMARY (CONTINUED) 7
CHAPTER THREE: OVERVIEW 8
DEFINITIONS 8
HISTORY 8
TABLE 1 HISTORICAL EVENTS IN CELL CULTURE DEVELOPMENT 9
TABLE 1 (CONTINUED) 10
TYPES OF CELL CULTURES 10
PRIMARY CULTURES 10
TABLE 2 ADVANTAGES AND DISADVANTAGES OF PRIMARY CELL
CULTURE 11
SECONDARY CELL CULTURE 11
CONTINUOUS CELL CULTURE 11
TABLE 3 ADVANTAGES AND DISADVANTAGES OF CONTINUOUS
CELL CULTURE 12
MORPHOLOGY OF CELLS IN CULTURE 12
FIBROBLASTIC CELLS 12
EPITHELIAL-LIKE CELLS 12
LYMPHOBLAST-LIKE CELLS 12
BASIC SYSTEMS FOR CELL CULTURE 12
TABLE 4 ADHERENT CULTURE VS SUSPENSION CULTURE 13
CELL LINE, CELL STRAIN AND TRANSFORMED CELL LINES 13
CHARACTERISTICS OF IMMORTALIZED CELL LINES 14
FACTORS AFFECTING CELL CULTURE 14
APPLICATIONS OF CELL CULTURE 15
MODEL SYSTEM 15
CANCER RESEARCH 15
VIROLOGY 15
TABLE 5 CULTURE MEDIA USED FOR THE PRODUCTION OF
VACCINES 16
TABLE 5 (CONTINUED) 17
GENETICALLY ENGINEERED PROTEINS 17
TABLE 6 POTENTIAL SOURCES OF CELL CULTURE ADDITIVES 18
Recombinant Thrombolytic Agents 19
TABLE 7 RECOMBINANT THROMBOLYTIC AGENTS 19
Recombinant Coagulation Factor 19
TABLE 8 RECOMBINANT COAGULATION FACTOR 20
Cytokines 20
Hematopoietic Growth Factors 21
Human Growth Hormones 22
Monoclonal Antibodies 22
TISSUE AND ORGAN REPLACEMENT 22
GENETIC COUNSELING 23
GENE THERAPY 23
PROBLEMS DURING CELL CULTURE 23
TOXICITY 23
MICROBIAL CONTAMINATION 23
Cross-Contamination 24
BASIC REQUIREMENTS OF CELL CULTURE 24
CELL CULTURE MEDIA 24
Basic Constituents of Media 24
Inorganic Salts 24
TABLE 9 THE ROLES OF DIFFERENT INORGANIC NUTRIENTS 25
Buffering Systems 25
Energy Source 26
Amino Acids 26
Vitamins 26
Proteins and Peptides 27
Fatty Acids and Lipids 27
Trace Elements 27
Antibiotics 28
TABLE 10 COMMONLY USED ANTIBIOTICS IN CELL CULTURES 28
Serum 29
Types of Cell Culture Media 29
Serum-Containing Media 29
TABLE 11 ADVANTAGES AND DISADVANTAGES OF SERUMCONTAINING
MEDIA 30
Serum-free Media 30
TABLE 12 ADVANTAGES AND DISADVANTAGES OF SERUM-FREE
MEDIA 31
Chemically Defined Media 31
Amino Acids 31
Carbohydrates 32
Inorganic Salts 32
Vitamins 32
Protein-Free Media 32
Selection of Cell Culture Media 33
Serum-Free Media: Reasons for Preference 33
Supplements for Serum-Free Media 33
Hormones 34
Transferrin 34
Lipids 34
Hydrolysates 35
SERUM 35
Role of Serum in Cell Culture 35
Serum Components 36
Growth Factors 36
Albumin 36
Protease Inhibitors 36
TABLE 13 NORMAL RANGE OF CONCENTRATION OF SERUM
CONSTITUENTS 36
TABLE 13 (CONTINUED) 37
Sources of Serum 37
Fetal Bovine Serum 37
Calf Serum 37
Calf Serum, Donor (Bovine) 37
Calf Serum, Newborn (Bovine) 37
Other Animal Sera 38
Chicken Serum 38
Dog Serum 38
Donor Donkey Serum 38
Donor Goat Serum 38
Donor Rat Serum 38
Rat Serum 38
Feline Serum 38
Guinea Pig Serum 39
Monkey Serum 39
Mouse Serum 39
Porcine Serum 39
Rabbit Serum 39
Sheep Serum 39
Horse Serum 39
Potential Problems with Serum 40
Serum Selection 40
CELL CULTURE REAGENTS 41
Amino Acids and Vitamins 41
Antibiotics and Antimycotics 41
Buffers 41
Cell Dissociation Agents 42
Growth Supplements 42
REGULATORY ASPECTS 42
APPROVALS OF BIOLOGICAL LICENSE APPLICATIONS 43
TABLE 14 APPROVALS OF BIOLOGICAL LICENSE APPLICATIONS,
2010 TO AUG 2011 43
TABLE 14 (CONTINUED) 44
ADMINISTRATIVE ACTIONS: BIOLOGICS 44
TABLE 15 ADMINISTRATIVE ACTIONS: BIOLOGICS, 2007 TO AUG
2011 44
TABLE 15 (CONTINUED) 45
TABLE 16 PRODUCT RECALLS, 2007 TO AUG 2011 46
TABLE 16 (CONTINUED) 47
TABLE 16 (CONTINUED) 48
LEADING MANUFACTURERS OF MEDIA 48
TABLE 17 LEADING MANUFACTURERS OF MEDIA 48
TABLE 17 (CONTINUED) 49
TABLE 17 (CONTINUED) 50
TABLE 17 (CONTINUED) 51
TABLE 17 (CONTINUED) 52
TABLE 17 (CONTINUED) 53
TABLE 17 (CONTINUED) 54
TABLE 18 LEADING MANUFACTURERS OF SERA 54
TABLE 18 (CONTINUED) 55
TABLE 18 (CONTINUED) 56
TABLE 19 LEADING MANUFACTURERS OF BIOLOGIC RESPONSE
MODIFIERS 57
TABLE 19 (CONTINUED) 58
TABLE 19 (CONTINUED) 59
TABLE 19 (CONTINUED) 60
TABLE 20 LEADING MANUFACTURERS OF CELL DISSOCIATION
REAGENTS 60
TABLE 20 (CONTINUED) 61
TABLE 21 LEADING MANUFACTURERS OF ANTIBIOTICS AND
ANTIMYCOTICS USED IN CELL CULTURE 62
TABLE 21 (CONTINUED) 63
TABLE 22 LEADING MANUFACTURERS OF OTHER REAGENTS 63
TABLE 22 (CONTINUED) 64
TABLE 22 (CONTINUED) 65
NEW DEVELOPMENTS 66
TABLE 23 NEW DEVELOPMENTS IN THE CELL CULTURE
INDUSTRY SINCE 2008 67
TABLE 23 (CONTINUED) 68
NEW DEVELOPMENTS IN APPLICATIONS 68
NEW DEVELOPMENTS IN APPLICATIONS (CONTINUED) 69
TABLE 24 NEW DEVELOPMENTS IN APPLICATION OF CELL
CULTURE 70
TABLE 24 (CONTINUED) 71
CHAPTER FOUR: GLOBAL MARKETS 72
GLOBAL MARKETS 72
GLOBAL MARKETS (CONTINUED) 73
TABLE 25 GLOBAL MARKET FOR CELL CULTURE PRODUCTS,
THROUGH 2016 ($ MILLIONS) 74
FIGURE 1 GLOBAL MARKET FOR CELL CULTURE PRODUCTS,
2009-2016 ($ MILLIONS) 74
MEDIA 75
MARKET REVENUE 76
TABLE 26 GLOBAL MARKET FOR MEDIA USED IN
BIOTECHNOLOGY BY REGION, THROUGH 2016 ($ MILLIONS) 76
FIGURE 2 GLOBAL MARKET FOR MEDIA USED IN
BIOTECHNOLOGY BY REGION, 2009-2016 ($ MILLIONS) 77
MARKET SHARES 77
TABLE 27 GLOBAL BIOTECHNOLOGY MEDIA MARKET SHARES BY
REGION, 2010 (%) 77
FIGURE 3 GLOBAL BIOTECHNOLOGY MEDIA MARKET SHARES BY
REGION, 2010 (%) 78
SERUM-FREE MEDIA AND SERUM-REQUIRING MEDIA 78
Serum-Free Media Market Revenue 79
TABLE 28 GLOBAL MARKET FOR SERUM-FREE MEDIA BY REGION,
THROUGH 2016 ($ MILLIONS) 79
FIGURE 4 GLOBAL MARKET FOR SERUM-FREE MEDIA BY REGION,
2009-2016 ($ MILLIONS) 79
Serum-Requiring Media Market Revenue 80
TABLE 29 GLOBAL MARKET FOR SERUM-REQUIRING MEDIA BY
REGION, THROUGH 2016 ($ MILLIONS) 80
FIGURE 5 GLOBAL MARKET FOR SERUM-REQUIRING MEDIA BY
REGION, 2009-2016 ($ MILLIONS) 81
POWDERED MEDIA AND LIQUID MEDIA 81
Powdered Media Market Revenue 82
TABLE 30 GLOBAL MARKET FOR POWDERED MEDIA, THROUGH
2016 ($ MILLIONS) 82
FIGURE 6 GLOBAL MARKET FOR POWDERED MEDIA, 2009-2016 ($
MILLIONS) 82
Liquid Media Market Revenue 83
TABLE 31 GLOBAL MARKET FOR LIQUID MEDIA BY REGION,
THROUGH 2016 ($ MILLIONS) 83
FIGURE 7 GLOBAL MARKET FOR LIQUID MEDIA BY REGION, 2009-
2016 ($ MILLIONS) 83
CLASSICAL AND SPECIALTY MEDIA 84
Classical Media Market Revenue 84
TABLE 32 GLOBAL MARKET FOR CLASSICAL MEDIA BY REGION,
THROUGH 2016 ($ MILLIONS) 85
FIGURE 8 GLOBAL MARKET FOR CLASSICAL MEDIA BY REGION,
2009–2016 ($ MILLIONS) 85
Specialty Media Market Revenue 86
TABLE 33 GLOBAL MARKET FOR SPECIALTY MEDIA BY REGION,
THROUGH 2016 ($ MILLIONS) 86
FIGURE 9 GLOBAL MARKET FOR SPECIALTY MEDIA BY REGION,
2009-2016 ($ MILLIONS) 86
SERA 87
MARKET REVENUE 88
TABLE 34 GLOBAL MARKET FOR SERA BY REGION, THROUGH
2016 ($ MILLIONS) 88
FIGURE 10 GLOBAL MARKET FOR SERA BY REGION, 2009–2016 ($
MILLIONS) 88
MARKET SHARES 89
TABLE 35 GLOBAL SERA MARKET SHARES BY REGION, 2010 (%) 89
FIGURE 11 GLOBAL SERA MARKET SHARES BY REGION, 2010 (%) 89
BOVINE SERA OR FETAL BOVINE SERA 90
TABLE 36 GLOBAL MARKET FOR BOVINE SERA BY REGION,
THROUGH 2016 ($ MILLIONS) 90
FIGURE 12 GLOBAL MARKET FOR BOVINE SERA BY REGION, 2009–
2016 ($ MILLIONS) 91
OTHER SERA 91
TABLE 37 GLOBAL MARKET FOR OTHER SERA BY REGION,
THROUGH 2016 ($ MILLIONS) 92
FIGURE 13 GLOBAL MARKET FOR OTHER SERA BY REGION, 2009-
2016 ($ MILLIONS) 92
REAGENTS 93
MARKET OVERVIEW 94
MARKET REVENUE 95
TABLE 38 GLOBAL MARKET FOR CELL CULTURE REAGENTS BY
REGION, THROUGH 2016 ($ MILLIONS) 95
FIGURE 14 GLOBAL MARKET FOR CELL CULTURE REAGENTS BY
REGION, 2009-2016 ($ MILLIONS) 96
MARKET SHARES 96
TABLE 39 GLOBAL CELL CULTURE REAGENT MARKET SHARES
BY REGION, 2010 (%) 96
FIGURE 15 GLOBAL CELL CULTURE REAGENT MARKET SHARES
BY REGION, 2010 (%) 97
BIOLOGICAL RESPONSE MODIFIERS 97
TABLE 40 GLOBAL MARKET FOR BIOLOGICAL RESPONSE
MODIFIERS BY REGION, THROUGH 2016 ($ MILLIONS) 97
FIGURE 16 GLOBAL MARKET FOR BIOLOGICAL RESPONSE
MODIFIERS BY REGION, 2009-2016 ($ MILLIONS) 98
Growth Factors 98
TABLE 41 GLOBAL MARKET FOR GROWTH FACTORS BY REGION,
THROUGH 2016 ($ MILLIONS) 99
FIGURE 17 GLOBAL MARKET FOR GROWTH FACTORS BY REGION,
2009- 2016 ($ MILLIONS) 99
Cytokines 99
TABLE 42 GLOBAL MARKET FOR CYTOKINES BY REGION,
THROUGH 2016 ($ MILLIONS) 100
FIGURE 18 GLOBAL MARKET FOR CYTOKINES BY REGION, 2009-
2016 ($ MILLIONS) 100
Other Biological Response Modifiers 100
TABLE 43 GLOBAL MARKET FOR OTHER BIOLOGICAL RESPONSE
MODIFIERS BY REGION, THROUGH 2016 ($ MILLIONS) 101
FIGURE 19 GLOBAL MARKET FOR OTHER BIOLOGICAL RESPONSE
MODIFIERS BY REGION, 2009-2016 ($ MILLIONS) 101
CELL DISSOCIATION REAGENTS 102
TABLE 44 GLOBAL MARKET FOR CELL DISSOCIATION REAGENTS
BY REGION, THROUGH 2016 ($ MILLIONS) 102
FIGURE 20 GLOBAL MARKET FOR CELL DISSOCIATION
REAGENTS BY REGION, 2009-2016 ($ MILLIONS) 102
OTHERS 103
TABLE 45 GLOBAL MARKET FOR OTHERS BY REGION, THROUGH
2016 ($ MILLIONS) 103
FIGURE 21 GLOBAL MARKET FOR OTHERS BY REGION, 2009-2016
($ MILLIONS) 104
CHAPTER FIVE: U S MARKET 105
TABLE 46 U S MARKET FOR CELL CULTURE PRODUCTS,
THROUGH 2016 ($ MILLIONS) 105
FIGURE 22 U S MARKET FOR CELL CULTURE PRODUCTS, 2009-
2016 ($ MILLIONS) 106
MEDIA 106
MARKET OVERVIEW 106
Market Overview (Continued) 107
MARKET REVENUE 108
TABLE 47 U S MARKET FOR CELL CULTURE MEDIA, THROUGH
2016 ($ MILLIONS) 108
FIGURE 23 U S MARKET FOR CELL CULTURE MEDIA, 2009-2016 ($
MILLIONS) 109
SERUM-REQUIRING AND SERUM-FREE MEDIA 109
Market Revenue 110
TABLE 48 U S MARKET FOR SERUM-REQUIRING AND SERUMFREE
MEDIA, THROUGH 2016 ($ MILLIONS) 111
FIGURE 24 U S MARKET FOR SERUM-REQUIRING AND SERUMFREE
MEDIA, 2009-2016 ($ MILLIONS) 111
POWDERED AND LIQUID MEDIA 111
Market Revenue 112
TABLE 49 U S MARKET FOR POWDERED AND LIQUID MEDIA,
THROUGH 2016 ($ MILLIONS) 112
FIGURE 25 U S MARKET FOR POWDERED AND LIQUID MEDIA,
2009-2016 ($ MILLIONS) 113
CLASSICAL AND SPECIALTY MEDIA 113
Market Revenue 114
TABLE 50 U S MARKET FOR CLASSICAL AND SPECIALTY MEDIA,
THROUGH 2016 ($ MILLIONS) 114
FIGURE 26 U S MARKET FOR CLASSICAL AND SPECIALTY MEDIA,
2009-2016 ($ MILLIONS) 114
SERA 115
MARKET OVERVIEW 115
MARKET REVENUE 116
TABLE 51 U S MARKET FOR BOVINE AND OTHER SERA,
THROUGH 2016 ($ MILLIONS) 116
FIGURE 27 U S MARKET FOR BOVINE AND OTHER SERA,
THROUGH 2016 ($ MILLIONS) 117
REAGENTS 117
MARKET OVERVIEW 118
Market Overview (Continued) 119
MARKET REVENUE 120
TABLE 52 U S MARKET FOR CELL CULTURE REAGENTS,
THROUGH 2016 ($ MILLIONS) 120
FIGURE 28 U S MARKET FOR CELL CULTURE REAGENTS, 2009-
2016 ($ MILLIONS) 120
BIOLOGICAL RESPONSE MODIFIERS 121
TABLE 53 U S MARKET FOR BIOLOGICAL RESPONSE MODIFIERS,
THROUGH 2016 ($ MILLIONS) 122
FIGURE 29 U S MARKET FOR BIOLOGICAL RESPONSE
MODIFIERS, 2009-2016 ($ MILLIONS) 122
U S MARKET LEADERS 123
MEDIA 123
Serum-Free Media 123
TABLE 54 U S MARKET SHARES OF SERUM-FREE MEDIA, 2010 (%) 123
FIGURE 30 U S MARKET SHARES OF SERUM-FREE MEDIA, 2010
(%) 124
Serum-Requiring/Containing Media 124
TABLE 55 U S MARKET SHARES OF SERUM-CONTAINING MEDIA,
2010 (%) 124
FIGURE 31 U S MARKET SHARES OF SERUM-CONTAINING
MEDIA, 2010 (%) 125
Powdered Media 125
TABLE 56 U S MARKET SHARES OF POWDERED MEDIA, 2010 (%) 125
FIGURE 32 U S MARKET SHARES OF POWDERED MEDIA, 2010 (%) 126
Liquid Media 126
TABLE 57 U S MARKET SHARES OF LIQUID MEDIA, 2010 (%) 126
FIGURE 33 U S MARKET SHARES OF LIQUID MEDIA, 2010 (%) 127
Classical Media 127
TABLE 58 U S MARKET SHARES OF CLASSICAL MEDIA, 2010 (%) 127
FIGURE 34 U S MARKET SHARES OF CLASSICAL MEDIA, 2010 (%) 128
Specialty Media 128
TABLE 59 U S MARKET SHARES OF SPECIALTY MEDIA, 2010 (%) 128
FIGURE 35 U S MARKET SHARES OF SPECIALTY MEDIA, 2010 (%) 129
SERA 129
Bovine Sera 129
TABLE 60 U S MARKET SHARES OF BOVINE SERA, 2010 (%) 129
FIGURE 36 U S MARKET SHARES OF BOVINE SERA, 2010 (%) 130
Other Sera 130
TABLE 61 U S MARKET SHARES OF OTHER SERA, 2010 (%) 130
FIGURE 37 U S MARKET SHARES OF OTHER SERA, 2010 (%) 131
REAGENTS 131
Biological Response Modifiers 131
TABLE 62 U S MARKET SHARES OF BIOLOGICAL RESPONSE
MODIFIERS, 2010 (%) 132
FIGURE 38 U S MARKET SHARES OF BIOLOGICAL RESPONSE
MODIFIERS, 2010 (%) 132
Cell Dissociation Reagents 132
TABLE 63 U S MARKET SHARES OF CELL DISSOCIATION
REAGENTS, 2010 (%) 133
FIGURE 39 U S MARKET SHARES OF CELL DISSOCIATION
REAGENTS, 2010 (%) 133
Other Reagents 133
TABLE 64 U S MARKET SHARES OF OTHER REAGENTS, 2010 (%) 134
FIGURE 40 U S MARKET SHARES OF OTHER REAGENTS, 2010 (%) 134
CHAPTER SIX: END USERS 135
MARKET SHARE OF APPLICATIONS 135
TABLE 65 GLOBAL MEDIA, SERA AND REAGENT MARKET SHARES
BY END USER, 2010 (%) 136
FIGURE 41 GLOBAL MEDIA, SERA AND REAGENT MARKET
SHARES BY END USER, 2010 (%) 136
RESEARCH SEGMENT 136
RESEARCH SEGMENT (CONTINUED) 137
RESEARCH SEGMENT (CONTINUED) 138
MARKET REVENUE 139
TABLE 66 GLOBAL SALES OF MEDIA, SERA AND REAGENTS IN
THE RESEARCH SEGMENT, THROUGH 2016 ($ MILLIONS) 139
FIGURE 42 GLOBAL SALES OF MEDIA, SERA AND REAGENTS IN
THE RESEARCH SEGMENT, 2009-2016 ($ MILLIONS) 140
PRODUCTION SEGMENT 140
PRODUCTION SEGMENT (CONTINUED) 141
MARKET REVENUE 142
TABLE 67 GLOBAL SALES OF MEDIA, SERA AND REAGENTS IN
THE PRODUCTION SEGMENT, THROUGH 2016 ($ MILLIONS) 142
FIGURE 43 GLOBAL SALES OF MEDIA, SERA AND REAGENTS IN
THE PRODUCTION SEGMENT, 2009-2016 ($ MILLIONS) 143
CONTRACT SEGMENT 143
CONTRACT SEGMENT (CONTINUED) 144
MARKET REVENUE 145
TABLE 68 GLOBAL SALES OF MEDIA, SERA AND REAGENTS IN
THE CONTRACT SEGMENT, THROUGH 2016 ($ MILLIONS) 146
FIGURE 44 GLOBAL SALES OF MEDIA, SERA AND REAGENTS IN
THE CONTRACT SEGMENT, 2009-2016 ($ MILLIONS) 146
OTHERS SEGMENT 146
MARKET REVENUE 147
TABLE 69 GLOBAL SALES OF MEDIA, SERA AND REAGENTS IN
THE OTHERS SEGMENT, THROUGH 2016 ($ MILLIONS) 148
FIGURE 45 GLOBAL SALES OF MEDIA, SERA AND REAGENTS IN
THE OTHERS SEGMENT, 2009-2016 ($ MILLIONS) 148
CHAPTER SEVEN: PATENT ANALYSIS 149
PATENTS BY YEAR 149
TABLE 70 NUMBER OF U S PATENTS ISSUED BY YEAR, 2007 TO
OCT 2011 150
FIGURE 46 U S PATENTS ISSUED BY YEAR, 2007 TO OCT 2011 (%) 150
PATENTS BY TYPE 150
TABLE 71 PATENTS BY TYPE FOR MEDIA, SERA AND REAGENTS
USED IN BIOTECHNOLOGY, 2007–2011 151
FIGURE 47 PATENTS BY TYPE FOR MEDIA, SERA AND REAGENTS
USED IN BIOTECHNOLOGY, 2007–2011 (NO OF PATENTS) 151
PATENTS BY COMPANY 151
TABLE 72 U S PATENTS ISSUED FOR MEDIA, SERA AND
REAGENTS IN BIOTECHNOLOGY BY COMPANY, 2007 TO OCT
2011 (NO ) 152
PATENTS BY COUNTRY 153
TABLE 73 U S PATENTS ISSUED FOR MEDIA, SERA AND
REAGENTS USED IN BIOTECHNOLOGY BY COUNTRY, 2007 TO
OCT 2011 (NO ) 153
TABLE 74 SHARES OF U S PATENTS ISSUED FOR MEDIA, SERA
AND REAGENTS USED IN BIOTECHNOLOGY BY COUNTRY,
2007–OCT 2011 (%) 154
PATENTS BY ASSIGNEE 154
TABLE 75 U S PATENTS ISSUED FOR MEDIA, SERA AND
REAGENTS USED IN BIOTECHNOLOGY BY TYPE OF END USER,
2007 TO OCT 2011 (NO ) 154
CHAPTER EIGHT: THE CURRENT SITUATION 155
REGIONAL MARKETS 155
UNITED STATES 155
EUROPE 156
ASIA 156
EMERGING MARKETS 157
TRENDS AND ISSUES IN THE CELL CULTURE MARKET 157
GLOBAL ECONOMY 157
INCREASED RESEARCH AND DEVELOPMENT BUDGET 157
TABLE 76 R&D BUDGETS OF TOP 10 COMPANIES IN 2009 AND 2010
($ BILLIONS) 158
GROWING DEMAND AND RICH PIPELINE OF
BIOTHERAPEUTICS 158
RESEARCH ON THERAPEUTIC VACCINES 159
BIOMEDICAL RESEARCH 160
STEM CELL RESEARCH 160
GOVERNMENT POLICIES ON RESEARCH 160
INNOVATIONS 161
ETHICAL AND ANIMAL WELFARE ISSUES 161
REGULATORY ISSUES 162
USE OF HUMAN BLOOD ALTERNATIVES 162
MERGERS, ACQUISITIONS AND ALLIANCES 163
SHIFT TOWARD CONTRACT MANUFACTURING 163
CHAPTER NINE: COMPANY PROFILES 164
ADVANCED BIOTECHNOLOGIES INC 164
AFFYMETRIX 164
AMRESCO LLC 165
ATHENA ENVIRONMENTAL SCIENCES INC 165
ATLANTA BIOLOGICALS INC 166
BD BIOSCIENCES 167
BIORECLAMATION INC 167
BOVOGEN BIOLOGICALS PTY LTD 168
CELL APPLICATIONS INC 168
CELL CULTURE TECHNOLOGIES GMBH 169
CLONTECH LABORATORIES INC 170
EQUITECH-BIO INC 170
GEMINI BIO-PRODUCTS 171
GENEX INDIA BIOSCIENCES PVT LTD 171
HIMEDIA LABORATORIES 172
INVITROGEN CORP 172
IRVINE SCIENTIFIC 173
J R SCIENTIFIC INC 174
LONZA 174
MEDIATECH INC 175
MEDOX BIOTECH INDIA PVT LTD 175
MILLIPORE CORP 176
MP BIOMEDICALS 177
PAA LABORATORIES 178
PEPROTECH INC 178
PROMOCELL GMBH 179
QUALITY BIOLOGICAL INC 179
R&D SYSTEMS 180
ROCHE APPLIED SCIENCES 181
SERA LABORATORIES INTERNATIONAL LTD 181
SERACARE LIFE SCIENCES INC 182
SIGMA-ALDRICH 182
STEMCELL TECHNOLOGIES 183
STEMCELLS INC 183
THERMO FISHER SCIENTIFIC INC 184
TICO EUROPE 185
VALLEY BIOMEDICAL PRODUCTS AND SERVICES INC 186
APPENDIX: ABBREVIATIONS 187
ABBREVIATIONS 187
ABBREVIATIONS (CONTINUED) 188
ABBREVIATIONS (CONTINUED) 189
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