LAS VEGAS, Jan. 15, 2025
The acute coronary syndrome market is experiencing significant growth, driven by the increasing prevalence of both acute myocardial infarction (AMI) and unstable angina, an aging global population, and advancements in diagnostic technologies. Innovations in treatment options, such as novel antiplatelet therapies, personalized medicine, and catheter-based interventions, are expanding market opportunities. Additionally, rising awareness and improved healthcare infrastructure, particularly in emerging markets, are expected to further fuel the growth of the ACS market in the coming years.
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LAS VEGAS, Jan. 15, 2025 /PRNewswire/ -- DelveInsight's Acute Coronary Syndrome Market Insights report includes a comprehensive understanding of current treatment practices, acute coronary syndrome emerging drugs, market share of individual therapies, and current and forecasted market size from 2020 to 2034, segmented into 7MM [the United States, the EU4 (Germany, France, Italy, and Spain) and the United Kingdom, and Japan].
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Key Takeaways from the Acute Coronary Syndrome Market Report
Discover which therapies are expected to grab the major acute coronary syndrome market share @ Acute Coronary Syndrome Market Report
Acute Coronary Syndrome Overview
Acute coronary syndrome (ACS) is a term used to describe a range of conditions resulting from the sudden reduction or interruption of blood flow to the heart. This condition is often caused by the rupture of an atherosclerotic plaque in the coronary arteries, leading to blood clot formation and subsequent blockage. The primary causes of ACS include atherosclerosis, thrombosis, and spasm of the coronary arteries. Risk factors include hypertension, high cholesterol, smoking, diabetes, and a sedentary lifestyle.
The symptoms of ACS can range from mild to severe and typically include chest pain or discomfort, shortness of breath, sweating, nausea, and dizziness. The chest pain is often described as a squeezing or pressure-like sensation. In more severe cases, such as a heart attack (myocardial infarction), symptoms can include radiating pain to the left arm, jaw, or back.
Diagnosis of ACS is based on clinical presentation, electrocardiogram (ECG) findings, and blood tests for cardiac biomarkers such as troponins, which are proteins released into the blood when the heart muscle is damaged. Imaging techniques, including coronary angiography, may be employed to visualize the extent of the blockage and determine the appropriate treatment, which could range from medication to invasive procedures like angioplasty or coronary artery bypass grafting (CABG). Early detection and treatment are crucial in improving outcomes for patients with ACS.
Acute Coronary Syndrome Epidemiology Segmentation
The acute coronary syndrome epidemiology section provides insights into the historical and current acute coronary syndrome patient pool and forecasted trends for the 7MM. It helps recognize the causes of current and forecasted patient trends by exploring numerous studies and views of key opinion leaders.
The acute coronary syndrome market report proffers epidemiological analysis for the study period 2020–2034 in the 7MM segmented into:
Acute Coronary Syndrome Treatment Market
The initial treatment for all cases of ACS includes aspirin (300 mg), a heparin bolus, and an intravenous heparin infusion, provided there are no contraindications. Antiplatelet therapy with either ticagrelor or clopidogrel is also recommended, with the choice depending on the cardiologist's preference. Ticagrelor is not administered to patients receiving thrombolysis. Supportive care, such as pain relief with morphine or fentanyl and oxygen for hypoxia, should be provided as needed. Sublingual or intravenous nitroglycerin may also be used for pain relief. In cases of inferior wall ischemia, nitroglycerin can cause significant hypotension and should be used cautiously. Continuous cardiac monitoring for arrhythmias is necessary.
Further treatment depends on whether the condition is STEMI, NSTEMI, or unstable angina. The American Heart Association recommends urgent catheterization and percutaneous intervention for STEMI, with a door-to-procedure time of under 90 minutes. If percutaneous intervention is not available or the patient cannot be transferred to the catheterization lab in under 120 minutes, thrombolytics (such as tenecteplase) are advised. The AHA guidelines suggest the door-to-needle (TNK or other thrombolytic) time should be under 30 minutes.
With the FDA approval of AGEPHA Pharma's LODOCO, patients with persistent inflammatory risk now have access to a treatment specifically designed to lower the risk of cardiovascular disease. LODOCO works by targeting the inflammatory pathways that contribute to major cardiac events. The current treatment market is divided into various therapeutic classes, including antiplatelet agents, anticoagulants, vasodilators, beta blockers, lipid-lowering drugs, ACE inhibitors, angiotensin-II receptor blockers (ARBs), and calcium channel blockers.
To know more about acute coronary syndrome treatment guidelines, visit @ Acute Coronary Syndrome Management
Acute Coronary Syndrome Pipeline Therapies and Key Companies
Discover more about acute coronary syndrome drugs in development @ Acute Coronary Syndrome Clinical Trials
Acute Coronary Syndrome Market Dynamics
The acute coronary syndrome market dynamics are expected to change in the coming years. The ACS market is primarily driven by the increasing prevalence of cardiovascular diseases, rising geriatric populations, and growing awareness of heart health. The expanding global burden of risk factors such as hypertension, diabetes, smoking, and obesity contributes significantly to the incidence of ACS. Technological advancements in diagnostic tools, such as high-sensitivity troponin assays and coronary imaging techniques, have improved early detection and intervention, driving market growth.
Additionally, the development of novel therapeutic agents, including anti-platelet therapies, thrombolytics, and advanced biologics, are further fueling the ACS treatment market. Healthcare infrastructure improvements, along with rising healthcare expenditure in emerging markets, also play a crucial role in expanding access to ACS care. Furthermore, ongoing research in personalized medicine and the adoption of minimally invasive procedures are enhancing the overall treatment landscape, providing a strong boost to market dynamics.
Furthermore, potential therapies are being investigated for the treatment of acute coronary syndrome, and it is safe to predict that the treatment space will significantly impact the acute coronary syndrome market during the forecast period. Moreover, the anticipated introduction of emerging therapies and devices with improved efficacy and a further improvement in the diagnosis rate are expected to drive the growth of the acute coronary syndrome market in the 7MM.
However several factors may impede the growth of the acute coronary syndrome market. One of the primary challenges is the high cost of treatment, including advanced therapies such as percutaneous coronary interventions (PCI) and novel drug-based therapies. These treatments are often expensive, limiting access in both developing and developed markets. Additionally, the complexity of diagnosing ACS early and accurately remains a challenge, with many patients presenting with non-specific symptoms, leading to delays in treatment and potential complications.
Regulatory hurdles also present barriers, as obtaining approvals for new drugs and devices can be time-consuming and costly. The market is further constrained by the presence of well-established therapies and the difficulty of demonstrating the clinical superiority of new treatments. Lastly, patient adherence to prescribed therapies, lifestyle changes, and the need for long-term management strategies complicate treatment outcomes, adding to the burden of ACS.
Acute Coronary Syndrome Market Report Metrics
Details
Study Period
2020–2034
Coverage
7MM [the United States, the EU4 (Germany, France, Italy, and Spain) and the United Kingdom, and Japan].
Acute Coronary Syndrome Market CAGR
7.7 %
Acute Coronary Syndrome Market Size in 2023
USD 2.6 Billion (7MM)
Key Acute Coronary Syndrome Companies
Agepha Pharma, Amgen, Merck, Regeneron and Sanofi, Genentech, Idorsia Pharmaceuticals, Viatris, Recardio, AstraZeneca, Faraday Pharmaceuticals, DalCor Pharmaceuticals, Roche, Jiangsu Vcare PharmaTech, CeleCor Therapeutics, Novo Nordisk, Bristol Myers Squibb, Johnson & Johnson Innovative Medicine, CellProthera, BioCardia, Kancera, Amgen, Arrowhead Pharmaceuticals, Abcentra, and others
Key Approved and Emerging Acute Coronary Syndrome Therapies
LODOCO (colchicine), REPATHA, ZONTIVITY, PRALUENT, Vicagrel, Selatogrel (ACT-246475), Dutogliptin, FARXIGA/FORXIGA (dapagliflozin), FDY-5301, Dalcetrapib (RO4607381), Zalunfiban (RUC 4), Ziltivekimab, Milvexian, ProtheraCytes, KAND567, Olpasiran (AMG 890), Orticumab, and others
Scope of the Acute Coronary Syndrome Market Report
Download the report to understand which factors are driving acute coronary syndrome market trends @ Acute Coronary Syndrome Market Trends
Table of Contents
1
Key Insights
2
Report Introduction
3
Executive Summary
4
Acute Coronary Syndrome Market Overview at a Glance
4.1
Market Share Distribution by Therapies (%) in 2020 in the 7MM
4.2
Market Share Distribution by Therapies (%) in 2034 in the 7MM
5
Epidemiology and Market Forecast Methodology
6
Key Events
7
Disease Background and Overview
7.1
Introduction
7.2
Sign and Symptoms
7.3
Risk Factors
7.4
Pathogenesis
7.5
Classification of ACS
7.6
Biomarkers
7.7
Diagnosis
7.7.1
Differential Diagnosis
8
Treatment and Management
8.1
Treatment and Management Guidelines
8.1.1
AHA/ACC/HFSA Guidelines for the Management of Heart Failure: Executive Summary: 2022
8.1.2
NICE Guidelines for Acute coronary syndromes: 2020
8.1.3
ESC Guidelines for the Management of Acute Myocardial Infarction in Patients Presenting With ST-Segment Elevation: 2017
8.1.4
ESC Guidelines for the Management of Acute Coronary Syndromes (ACS): 2023
8.1.5
ACCF/AHA Guideline for the Management of ST-Elevation Myocardial Infarction
8.1.6
Guideline Adherence and Longterm Clinical Outcomes in Patients with AMI in Japan
9
Epidemiology and Patient Population of ACS in the 7MM
9.1
Key Findings
9.2
Assumptions and Rationale
9.3
Total Incident Cases of ACS in the 7MM
9.4
The United States
9.4.1
Total Incident Cases of ACS in the United States
9.4.2
Type-specific Incident Cases of ACS in the United States
9.4.3
Type-specific Incident Cases of AMI in the United States
9.4.4
Gender-specific Incident Cases of ACS in the United States
9.5
EU4 and the UK
9.5.1
Total Incident Cases of ACS in EU4 and the UK
9.5.2
Type-specific Incident Cases of ACS in EU4 and the UK
9.5.3
Type-specific Incident Cases of AMI in EU4 and the UK
9.5.4
Gender-specific Incident Cases of ACS in EU4 and the UK
9.6
Japan
9.6.1
Total Incident Cases of ACS in Japan
9.6.2
Type-specific Incident Cases of ACS in Japan
9.6.3
Type-specific Incident Cases of AMI in Japan
9.6.4
Gender-specific Incident Cases of ACS in Japan
10
Patient Journey
11
Marketed Drugs
11.1
Key Cross Competition
11.2
LODOCO (colchicine): AGEPHA Pharma
11.2.1
Product Description
11.2.2
Regulatory Milestones
11.2.3
Other Developmental Activities
11.2.4
Safety and Efficacy
11.3
TNKase (tenecteplase): Genentech
11.3.1
Product Description
11.3.2
Regulatory Milestones
11.3.3
Safety and Efficacy
11.4
REPATHA (evolocumab): Amgen
11.4.1
Product Description
11.4.2
Regulatory Milestones
11.4.3
Other Developmental Activities
11.4.4
Safety and Efficacy
11.5
ZONTIVITY (vorapaxar): Merck
11.5.1
Product Description
11.5.2
Regulatory Milestones
11.5.3
Other Developmental Activity
11.5.4
Safety and Efficacy
11.6
PRALUENT (alirocumab): Regeneron and Sanofi
11.6.1
Product Description
11.6.2
Regulatory Milestones
11.6.3
Other Developmental Activities
11.6.4
Safety and Efficacy
12
Other Marketed Assets
12.1
Key Cross Competition
12.2
INSPRA (eplerenone): Pfizer
12.2.1
Product Description
12.2.2
Regulatory milestones
12.2.3
Safety and efficacy
12.3
PLAVIX (clopidogrel bisulfate): Sanofi-Aventis/Bristol-Myers Squibb
12.3.1
Product Description
12.3.2
Regulatory milestones
12.3.3
Other developmental activities
12.3.4
Safety and efficacy
12.4
BRILINTA/BRILIQUE (ticagrelor): AstraZeneca
12.4.1
Product Description
12.4.2
Regulatory milestones
12.4.3
Safety and efficacy
12.5
EFFIENT/EFIENT (prasugrel): Daiichi Sankyo/Eli Lilly and Company
12.5.1
Product Description
12.5.2
Regulatory milestones
12.5.3
Other development activity
12.5.4
Safety and efficacy
12.6
ATACAND (candesartan): AstraZeneca/Takeda
12.6.1
Product Description
12.6.2
Regulatory milestones
12.7
DIOVAN (valsartan): Novartis
12.7.1
Product Description
12.7.2
Regulatory milestones
12.7.3
Safety and efficacy
13
Emerging Therapies
13.1
Key Cross Competition
13.2
Selatogrel (ACT-246475): Idorsia Pharmaceuticals and Viatris
13.2.1
Product Description
13.2.2
Other Developmental Activities
13.2.3
Clinical Development
13.2.4
Safety and Efficacy
13.2.5
Analyst View
13.3
Dutogliptin: Recardio
13.3.1
Product Description
13.3.2
Other Developmental Activities
13.3.3
Clinical Development
13.3.4
Safety and Efficacy
13.3.5
Analyst View
13.4
FARXIGA/FORXIGA (dapagliflozin): AstraZeneca
13.4.1
Product Description
13.4.2
Other Developmental Activities
13.4.3
Clinical Development
13.4.4
Safety and efficacy
13.4.5
Analyst View
13.5
FDY-5301: Faraday Pharmaceuticals
13.5.1
Product Description
13.5.2
Other Developmental Activity
13.5.3
Clinical Development
13.5.4
Safety and Efficacy
13.5.5
Analyst View
13.6
Dalcetrapib (RO4607381): DalCor Pharmaceuticals and Roche
13.6.1
Product Description
13.6.2
Other Developmental Activities
13.6.3
Clinical Development
13.6.4
Safety and Efficacy
13.6.5
Analyst View
13.7
Vicagrel: Jiangsu Vcare PharmaTech
13.7.1
Product Description
13.7.2
Other Developmental Activities
13.7.3
Clinical Development
13.7.4
Analyst View
13.8
Zalunfiban (RUC 4): CeleCor Therapeutics
13.8.1
Product Description
13.8.2
Other Developmental Activities
13.8.3
Clinical Development
13.8.4
Safety and Efficacy
13.8.5
Analyst View
13.9
Ziltivekimab: Novo Nordisk
13.9.1
Product Description
13.9.2
Other Developmental Activities
13.9.3
Clinical Development
13.9.4
Analyst View
13.10
Milvexian: Bristol Myers Squibb and Johnson & Johnson Innovative Medicine
13.10.1
Product Description
13.10.2
Other Developmental Activities
13.10.3
Clinical Development
13.10.4
Analyst View
13.11
ProtheraCytes: CellProthera and BioCardia
13.11.1
Product Description
13.11.2
Other Developmental Activities
13.11.3
Clinical Development
13.11.4
Safety and Efficacy
13.11.5
Analyst View
13.12
KAND567: Kancera
13.12.1
Product Description
13.12.2
Other Developmental Activities
13.12.3
Clinical Development
13.12.4
Safety and Efficacy
13.12.5
Analyst View
13.13
Olpasiran (AMG 890): Amgen and Arrowhead Pharmaceuticals
13.13.1
Product Description
13.13.2
Other Developmental Activities
13.13.3
Clinical Development
13.13.4
Safety and Efficacy
13.13.5
Analyst View
13.14
Orticumab: Abcentra
13.14.1
Product Description
13.14.2
Other Developmental Activities
13.14.3
Clinical Development
13.14.4
Analyst View
14
Acute Coronary Syndrome (ACS): 7MM Analysis
14.1
Key Findings
14.2
Market Outlook
14.3
Conjoint Analysis
14.4
Key Market Forecast Assumptions
14.5
Total Market Size of ACS in the 7MM
14.6
United States Market Size
14.6.1
Total Market Size of ACS in the United States
14.6.2
Market Size of ACS by Therapies in the United States
14.7
EU4 and the UK Market Size
14.7.1
Total Market Size of ACS in EU4 and the UK
14.7.2
Market Size of ACS by Therapies in EU4 and the UK
14.8
Japan Market Size
14.8.1
Total Market Size of ACS in Japan
14.8.2
Market Size of ACS by Therapies in Japan
15
Unmet Needs
16
SWOT Analysis
17
KOL Views
18
Market Access and Reimbursement
18.1
United States
18.1.1
Centre for Medicare and Medicaid Services (CMS)
18.2
EU4 and the UK
18.2.1
Germany
18.2.2
France
18.2.3
Italy
18.2.4
Spain
18.2.5
United Kingdom
18.3
Japan
18.3.1
MHLW
18.4
Reimbursement Scenario and Key HTA Decisions in ACS
19
Appendix
19.1
Bibliography
19.2
Report Methodology
20
DelveInsight Capabilities
21
Disclaimer
22
About DelveInsight
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