DURHAM, N.C., Dec. 11, 2024
DURHAM, N.C., Dec. 11, 2024 /PRNewswire/ -- Target RWE, real-world evidence leader, shared two studies at The Liver Meeting 2024 that revealed insights on the NASH-CHECK1 patient-reported outcome measure (PROM) tailored for patients with metabolic dysfunction-associated steatotic liver disease (MASLD).
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The previously developed MASLD-specific NASH-CHECK PROM provides a robust and validated tool for assessing patient-reported outcomes over time in drug development settings. Recent findings utilizing the NASH-CHECK PROM in a real-world setting of patients with MASLD in the U.S. include:
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Stability of the NASH-CHECK patient-reported outcome measure over time in patients with metabolic dysfunction-associated steatotic liver disease and stable clinical status
A prospective assessment of the impact of decompensation of cirrhosis on patient-reported outcomes in metabolic dysfunction-associated steatotic liver disease
"The findings from these analyses not only demonstrate the stability of the NASH-CHECK measure but also highlight the nuanced ways in which disease progression impacts patients. This knowledge will help shape patient-centered approaches in managing MASLD and MASH, supporting regulatory efforts to ensure that treatments meet patient needs," said Arun J. Sanyal, MBBS, MD, Director of Stravitz-Sanyal Institute for Liver Disease and Metabolic Health, Interim Chair of Division of Gastroenterology, Hepatology, and Nutrition, Z. Reno Vlahcevic Professor of Medicine, Physiology, and Molecular Pathology, Virginia Commonwealth University School of Medicine. Dr. Sanyal is also co-chair of the TARGET-NASH steering committee and co-author of both studies.
To learn more about Target RWE real-world registries and access a full list of all publications, visit targetrwe.com/research/publications/.
1Doward, Lynda C., et al. (2021). Development of a patient-reported outcome measure for non-alcoholic steatohepatitis (NASH-CHECK): results of a qualitative study. The Patient-Patient-Centered Outcomes Research, 14, 533-543
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