- Punicalagin from pomegranate ameliorates TNF-α/IFN-γ-induced inflammatory responses in HaCaT cells via regulation of SIRT1/STAT3 axis and Nrf2/HO-1 signaling pathway - (https://pubmed.ncbi.nlm.nih.gov/38367463/)
- Potent health effects of pomegranate - (https://pubmed.ncbi.nlm.nih.gov/24800189/)
- Human Inflammaging - (https://pubmed.ncbi.nlm.nih.gov/31055573/)
- Effects of Pomegranate Extract on Inflammatory Markers and Cardiometabolic Risk Factors in Adults Aged 55-70 Years: A Randomised Controlled Parallel Trial - (https://pmc.ncbi.nlm.nih.gov/articles/PMC11990117/)
About
Once considered an exotic fruit reserved for festive occasions or special recipes, the pomegranate is now earning its spot as a daily superfruit. With its jewel-like seeds and sweet-tart flavor, the pomegranate is more than just a beautiful snack- it is packed with health benefits that can support your heart, brain, and overall well-being as you age.
Recent research has started to uncover what happens when adults over 55 incorporate pomegranate extract into their daily routine. Let’s dive into what the science says- and what might happen if you enjoy a whole pomegranate a day.
Did You Know?
Pomegranates can contain up to 1,400 seeds. That's a whole lot of antioxidants in one fruit!
#pomegranatepower #healthyaging #inflammationbuster #fruitfacts #medindia





Health Benefits of Pomegranate
Pomegranates are rich in polyphenols- plant-based compounds that protect your cells from damage. One standout is punicalagin, a powerful antioxidant found in the fruit’s peel and juice(1✔ ✔Trusted Source
Punicalagin from pomegranate ameliorates TNF-α/IFN-γ-induced inflammatory responses in HaCaT cells via regulation of SIRT1/STAT3 axis and Nrf2/HO-1 signaling pathway
Go to source). In fact, pomegranates contain more antioxidants than many other superfoods, including green tea. The antioxidant potential of pomegranate juice is more than that of red wine(2✔ ✔Trusted Source
Potent health effects of pomegranate
Go to source).
These antioxidants play a big role in fighting chronic, low-grade inflammation, a condition that quietly worsens with age- a phenomenon scientists call inflammaging. Inflammaging has been linked to a wide range of age-related illnesses like diabetes, heart disease, and even cognitive decline(3✔ ✔Trusted Source
Human Inflammaging
Go to source).
Pomegranate Extract Benefits Older Adults
A recent study published in the journal Nutrients investigated how pomegranate extract (PE) affected adults aged 55 to 70. Most participants were women with average body weight and slightly elevated blood pressure- nothing that raised alarm bells.
But beneath the surface, many had hidden risks: high cholesterol levels, signs of low-grade inflammation, and other early markers of chronic disease. Over time, the group that consumed PE daily saw some fascinating improvements(4✔ ✔Trusted Source
Effects of Pomegranate Extract on Inflammatory Markers and Cardiometabolic Risk Factors in Adults Aged 55-70 Years: A Randomised Controlled Parallel Trial
Go to source).
Pomegranate Extract Helps Boost Heart Health
The biggest win? A reduction in systolic blood pressure (the top number in your BP reading). On average, participants who took pomegranate extract experienced a 5.2 mm Hg drop in systolic blood pressure- enough to reduce the risk of major heart events by 10%(4✔ ✔Trusted Source
Effects of Pomegranate Extract on Inflammatory Markers and Cardiometabolic Risk Factors in Adults Aged 55-70 Years: A Randomised Controlled Parallel Trial
Go to source).
While diastolic blood pressure (the bottom number) also dipped slightly, the change wasn’t significant. Still, the improvement in systolic pressure alone makes pomegranate a fruit to take seriously if you are watching your heart health.
Pomegranate Extract Reduces Chronic Inflammation
The PE group also showed decreases in two key inflammatory markers: IL-6 and IL1-β. While other markers like CRP and TNF-α didn’t show major changes, they trended downward too(4✔ ✔Trusted Source
Effects of Pomegranate Extract on Inflammatory Markers and Cardiometabolic Risk Factors in Adults Aged 55-70 Years: A Randomised Controlled Parallel Trial
Go to source).
Why does this matter? Chronic inflammation is a silent contributor to many serious diseases, and controlling it can make a big difference in long-term health. The antioxidants in pomegranate appear to calm this internal fire, at least in part.
Interestingly, the study didn’t see big changes in cholesterol, triglycerides, or blood sugar. That’s likely because most participants had normal weight and didn’t have major metabolic issues to begin with. However, the fact that PE didn’t worsen these markers is still a plus.

Adding Pomegranate to Your Diet
Eating one pomegranate daily- seeds and all- can mimic many of the benefits seen in the study. Each fruit offers fiber, vitamins C and K, and a generous dose of polyphenols. While the study used a concentrated extract, the fruit itself is still highly beneficial.
Pomegranates are also sustainable. They require less water and adapt well to different soil types- great news for the environment-conscious eater.
Who Should Try Adding Pomegranate to Their Diet?
Anyone over 50 looking to support healthy aging could benefit from adding pomegranate to their daily diet- especially those with slightly elevated blood pressure or early signs of inflammation. While it won’t replace medications for serious conditions, it can be a simple, delicious way to protect your health over time.
Are There Any Side-Effects of Pomegranate Extract?
Good news: the supplement was well tolerated with no major side effects. That means eating the whole fruit is likely safe too, unless you have specific allergies or are on medications that interact with antioxidants.
A pomegranate a day might not keep the doctor away completely- but it certainly puts you on a better path. With regular consumption, this vibrant fruit could help calm inflammation, support heart health, and promote graceful aging.
It's a small habit with mighty potential. So, go ahead- crack open a pomegranate, sprinkle the seeds on your yogurt, or eat them straight from the bowl. Your future self might thank you.