Categorization of Drug Toxicity
Most Adverse Drug reactions are related to dose. Dose-related reactions are usually predictable, and those unrelated to dose are usually unpredictable.
Side effects
Side effects are Pharmacologic effect, which occurs even when taking normal dosage schedule.
Diarrhea is a common side effect in persons taking oral antibiotics due to killing of normal micro-flora of Gastro-intestinal tract in addition to killing pathogenic bacteria.
Over Dosage:
Toxicity, which occurs due to over dosage of the drug higher than the therapeutic range for a particular patient.
The severity of the toxicity is usually dose-related.
Toxicity may result from decrease in drug clearance in patients with impaired renal clearance.
Drug Allergies:
Drug allergies are mostly common which is not dosage related, Toxicity is not related to dosage, drug allergy may cause serious toxicity.
