JCI Insight 2020 Jan 30
Differences in the induced latent HIV reservoir in perinatal and adult infection.
Dhummakupt A, Rubens JH, Anderson T, Powell L, Nonyane BA, Siems LV, Collinson-Streng A, Nilles TL, Jones RB, Tepper V, Agwu A, Persaud D
The HIV latent reservoir in resting memory CD4+ T cells prevents cure. Therapeutics to reactivate and eliminate this reservoir are in clinical trials ...
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Source: PubMed
JCI Insight
HIV vaccine delayed boosting increases Env variable region 2-specific antibody effector functions.
Easterhoff D, Pollara J, Luo K, Janus B, Gohain N, Williams LD, Tay MZ, Monroe A, Peachman K, Choe M, Min S, Lusso P, Zhang P, Go EP, Desaire H, Bonsignori M, Hwang KK, Beck C, Kakalis M, O'Connell RJ, Vasan S, Kim JH, Michael NL, Excler JL, Robb ML, Rerks-Ngarm S, Kaewkungwal J, Pitisuttithum P, Nitayaphan S, Sinangil F, Tartaglia J, Phogat S, Wiehe K, Saunders KO, Montefiori DC, Tomaras GD, Moody MA, Arthos J, Rao M, Joyce MG, Ofek GA, Ferrari G, Haynes BF
In the RV144 HIV-1 phase III trial, vaccine efficacy directly correlated with the magnitude of the variable region 2-specific (V2-specific) IgG antibo ...
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Source: PubMed
J. Clin. Invest. 2020 Jan 07
HIV persists throughout deep tissues with repopulation from multiple anatomical sources.
Chaillon A, Gianella S, Dellicour S, Rawlings SA, Schlub TE, Faria De Oliveira M, Ignacio C, Porrachia M, Vrancken B, Smith DM
Understanding HIV dynamics across the human body is important for cure efforts. This goal has been hampered by technical difficulties and the challeng ...
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Source: PubMed
Drugs Today
Bictegravir, a novel integrase inhibitor for the treatment of HIV infection.
Zeuli J, Rizza S, Bhatia R, Temesgen Z
Bictegravir (BIC), a second-generation integrase strand transfer inhibitor (INSTI) approved for HIV treatment in fixed-dose combination with emtricita ...
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Source: PubMed
Rev. Esp. Salud Publica
[Monitoring and evaluation of hiv in catalonia, getting closer to the 90-90-90 objectives].
Agustí Benito C, Reyes-Urueña J, Sentís Fuster A, Folch Toda C, Fernàndez-López L, Bruguera Riera A, López-Corbeto E, Ferrer Serret L, Conway A, Moreno Fornes S, Egea-Cortés L, Colom Farran J, Casabona I Barbarà J
Epidemiological surveillance of HIV infection allows monitoring its incidence as well as possible epidemiological changes, allowing specific intervent ...
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Source: PubMed
