Biochem. Biophys. Res. Commun. 2020 Jan 29
ALS-causing D169G mutation disrupts the ATP-binding capacity of TDP-43 RRM1 domain.
Dang M, Song J
TDP-43 inclusion is a pathological hallmark for ~97% ALS and ~45% FTD patients. So far, >50 ALS-causing mutations have been identified, most of which ...
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Source: PubMed
Stem Cell Res
The mRNA-based reprogramming of fibroblasts from a SOD1E101G familial amyotrophic lateral sclerosis patient to induced pluripotent stem cell line UOWi007.
Balez R, Berg T, Bax M, Muñoz SS, Cabral-da-Silva MC, Engel M, Do-Ha D, Stevens CH, Rowe D, Yang S, Blair IP, Ooi L
Dermal fibroblasts were donated by a 43 year old male patient with clinically diagnosed familial amyotrophic lateral sclerosis (ALS), carrying the SOD ...
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Source: PubMed
Sci Rep
Repeated intramuscular transplantations of hUCB-MSCs improves motor function and survival in the SOD1 G93A mice through activation of AMPK.
Kook MG, Lee S, Shin N, Kong D, Kim DH, Kim MS, Kang HK, Choi SW, Kang KS
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease that is characterized by loss of motor neurons and degeneration of neuromuscu ...
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Source: PubMed
Acta Neuropathol Commun
DNA damage accumulates and responses are engaged in human ALS brain and spinal motor neurons and DNA repair is activatable in iPSC-derived motor neurons with SOD1 mutations.
Kim BW, Jeong YE, Wong M, Martin LJ
DNA damage is implicated in the pathogenesis of amyotrophic lateral sclerosis (ALS). However, relationships between DNA damage accumulation, DNA damag ...
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Source: PubMed
Amyotroph Lateral Scler Frontotemporal Degener 2020 Jan 31
Telehealth as part of specialized ALS care: feasibility and user experiences with "ALS home-monitoring and coaching".
Helleman J, Van Eenennaam R, Kruitwagen ET, Kruithof WJ, Slappendel MJ, Van Den Berg LH, Visser-Meily JMA, Beelen A
Objective: To evaluate the use of telehealth as part of specialized care for patients with amyotrophic lateral sclerosis (ALS) and the user experience ...
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Source: PubMed
