J. Biomol. NMR 2020 Feb 01
Mass spectrometry assisted arginine side chains assignment of NMR resonances in natural abundance proteins.
Lu J, Zhou F, Liu W, Yu F
Arginine side chains play critical roles in many protein-ligand interactions and enzyme catalysis. Unambiguous resonance assignment is a prerequisite ...
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Source: PubMed
Curr. Diab. Rep.
Policy Implications of Artificial Intelligence and Machine Learning in Diabetes Management.
Broome DT, Hilton CB, Mehta N
Machine learning (ML) is increasingly being studied for the screening, diagnosis, and management of diabetes and its complications. Although various m ...
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Source: PubMed
J. Inorg. Biochem.
The assembly and antitumor activity of lycium barbarum polysaccharide-platinum-based conjugates.
Wang Y, Han Q, Bai F, Luo Q, Wu M, Song G, Zhang H, Wang Y
In this work, the new polysaccharide-platinum conjugates of 5-aminosalicylic acid modified lycium barbarum polysaccharide linking platinum compounds w ...
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Source: PubMed
Eur J Med Chem
Discovery of novel akt1 inhibitor induces autophagy associated death in hepatocellular carcinoma cells.
Yu M, Zeng M, Pan Z, Wu F, Guo L, He G
In this study, a series of thieno [2,3-d]pyrimidine derivatives were designed, synthesized and evaluated as novel AKT1 inhibitors. In vitro antitumor ...
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Source: PubMed
Int J Pharm 2020 Jan 30
Controlled In Vitro Delivery of Voriconazole and Diclofenac to the Cornea using Contact Lenses for the Treatment of Acanthamoeba Keratitis.
Morgan SR, Pilia N, Hewitt M, Moses RL, Moseley R, Lewis PN, Morrison PWJ, Kelly SL, Parker JE, Whitaker D, Quantock AJ, Heard CM
Acanthamoeba keratitis is caused by a protozoal infection of the cornea, with 80% of cases involving the improper use of contact lenses. The infection ...
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Source: PubMed
