J. Rheumatol. 2020 Feb 01
Do serum urate-associated genetic variants influence gout risk in people on diuretics? Analysis of the UK Biobank.
Narang RK, Gamble G, Phipps-Green AJ, Topless R, Cadzow M, Stamp LK, Merriman TR, Dalbeth N
The aim of this study was to determine whether serum urate-associated genetic variants differ in their influence on gout risk in people taking a diure ...
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Source: PubMed
Sci. Total Environ.
Wastewater-based estimation of the prevalence of gout in Australia.
Ahmed F, Tscharke B, O'Brien J, Thompson J, Samanipour S, Choi P, Li J, Mueller JF, Thomas K
Allopurinol, a first-line gout treatment drug in Australia, was assessed as a wastewater-based epidemiology biomarker of gout via quantification of th ...
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Source: PubMed
Med. Hypotheses
Hyperuricemia as a potential plausible risk factor for periodontitis.
Chen ZY, Ye LW, Zhao L, Liang ZJ, Yu T, Gao J
Elevated blood uric acid (UA) levels have been positively associated with the severity of periodontitis. It thus brings out a hypothesis that hyperuri ...
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Source: PubMed
J Control Release 2020 Jan 29
Intramolecular distance in the conjugate of urate oxidase and fatty acid governs FcRn binding and serum half-life in vivo.
Cho J, Park J, Kim S, Kim JC, Tae G, Jin MS, Kwon I
Therapeutic proteins are indispensable for treatment of various human diseases. However, intrinsic short serum half-lives of proteins are still big hu ...
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Source: PubMed
Genetics 2020 Jan 31
Contribution of Rare Variants of the SLC22A12 Gene to the Missing Heritability of Serum Urate Levels.
Misawa K, Hasegawa T, Mishima E, Jutabha P, Ouchi M, Kojima K, Kawai Y, Matsuo M, Anzai N, Nagasaki M
Gout is a common arthritis caused by monosodium urate crystals. The heritability of serum urate levels is estimated to be 30?70%; however, common gene ...
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Source: PubMed
