Biol. Blood Marrow Transplant. 2020 Jan 30
Goal-oriented monitoring of cyclosporine is effective for graft-versus-host disease prevention after Hematopoietic Stem Cell Transplantation in Sickle Cell Disease and Thalassemia major.
Gauthier A, Bleyzac N, Garnier N, Kebaili K, Joly P, Goutagny MP, Mollet I, Goutelle S, Renard C, Bertrand Y
Graft-versus-host disease (GvHD) is an important challenge and one of the major causes of morbidity and mortality in children after hematopoietic stem ...
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Source: PubMed
Biol. Blood Marrow Transplant. 2020 Jan 29
Nilotinib treatment of patients affected by chronic graft-versus-host disease reduces collagen production and skin fibrosis by down-modulating the TGF-ß and p-SMAD pathway.
Busilacchi Elena M, Andrea C, Giorgia M, Giovanni T, Jacopo O, Antonella P, Nadia V, Luca B, Anna C, Gaia G, Daniela M, Olivieri A
The present study was conducted to investigate cellular and molecular features of chronic graft-versus-host disease fibroblasts (GVHD-Fbs) and to asse ...
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Source: PubMed
Methods Mol. Biol.
Next Generation of Adoptive T Cell Therapy Using CRISPR/Cas9 Technology: Universal or Boosted?
Wälchli S, Sioud M
Adoptive T cell therapy (ACT) using either chimeric antigen receptor (CAR)- or T cell receptor (TCR)-engineered lymphocytes has emerged as a promising ...
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Source: PubMed
Ann. Hematol. 2020 Feb 01
Reduced dose of MTX for GVHD prophylaxis promotes engraftment and decreases non-relapse mortality in umbilical cord blood transplantation.
Shiratori S, Ohigashi H, Takahashi S, Ara T, Goto H, Nakagawa M, Sugita J, Onozawa M, Kahata K, Endo T, Hashimoto D, Teshima T
Although a combination of calcineurin inhibitor and methotrexate (MTX) is used for graft-versus-host disease (GVHD) prophylaxis in umbilical cord bloo ...
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Source: PubMed
Ann. Hematol. 2020 Jan 31
Reduced-intensity haploidentical peripheral blood stem cell transplantation using low-dose thymoglobulin for aggressive adult T cell leukemia/lymphoma patients in non-complete remission.
Hirosawa M, Yamaguchi T, Tanaka A, Kominato Y, Higashi T, Morimoto H, Tsukada J
Haploidentical hematopoietic stem cell transplantation (haplo-HSCT) has been accepted as a treatment option for aggressive (acute or lymphoma type) ad ...
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Source: PubMed
