Pharmacol. Res.
The role of hepcidin and iron homeostasis in atherosclerosis.
Wunderer F, Traeger L, Sigurslid HH, Meybohm P, Bloch DB, Malhotra R
Atherosclerotic cardiovascular disease is a major burden on global health and a leading cause of death worldwide. The pathophysiology of this chronic ...
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Source: PubMed
Hemasphere
SLN124, a GalNAc-siRNA Conjugate Targeting TMPRSS6, Efficiently Prevents Iron Overload in Hereditary Haemochromatosis Type 1.
Altamura S, Schaeper U, Dames S, Löffler K, Eisermann M, Frauendorf C, Müdder K, Neves J, Muckenthaler MU
Supplemental Digital Content is available in the text. ...
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Source: PubMed
Zhonghua Gan Zang Bing Za Zhi
[Hemochromatosis International: therapeutic recommendations in HFE hemochromatosis for p.Cys282Tyr homozygous genotype].
Zhang W, Huang J, Ou XJ, You H, Jia JD
Hereditary hemochromatosis is a kind of hereditary metabolic liver disorders. It is caused by mutations in genes related to hemochromatosis, which lea ...
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Source: PubMed
Arch. Biochem. Biophys.
The effects of iron overload on mitochondrial function, mitochondrial dynamics, and ferroptosis in cardiomyocytes.
Sumneang N, Siri-Angkul N, Kumfu S, Chattipakorn SC, Chattipakorn N
Excessive iron accumulation in the heart can lead to iron overload cardiomyopathy (IOC), the leading cause of death in hemochromatosis patients. Curre ...
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Source: PubMed
