Toxicol Rep
Determination and prediction of permeability across intestinal epithelial cell monolayer of a diverse range of industrial chemicals/drugs for estimation of oral absorption as a putative marker of hepatotoxicity.
Kamiya Y, Takaku H, Yamada R, Akase C, Abe Y, Sekiguchi Y, Murayama N, Shimizu M, Kitajima M, Shono F, Funatsu K, Yamazaki H
Apparent permeability coefficients (Papp) across a human intestinal epithelial Caco-2 cell monolayer were measured for a range of industrial/drug chem ...
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Source: PubMed
Br. J. Pharmacol. 2020 Jan 28
Anabolic Androgenic Steroid Abuse in the United Kingdom; An Update The increasing popularity of anabolic androgenic steroids.
Mullen C, Whalley BJ, Schifano F, Baker JS
Anabolic androgenic steroids (AASs) are prescribed for medical conditions related to low testosterone. Abuse of AASs has surged as they become increas ...
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Source: PubMed
Euroasian J Hepatogastroenterol
Drug-induced Liver Injury Caused by Phenprobamate: Strong Probability Due to Repeated Toxicity.
Duzenli T, Tanoglu A, Akyol T, Kara M, Yazgan Y
Drug-induced liver injury (DILI) is an important cause of morbidity and mortality. DILI can even cause acute liver failure and the need for liver tran ...
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Source: PubMed
Aliment. Pharmacol. Ther. 2020 Jan 27
Systematic review: ibuprofen-induced liver injury.
Zoubek ME, Lucena MI, Andrade RJ, Stephens C
Nonsteroidal anti-inflammatory drugs (NSAIDs) are a leading cause of drug-induced liver injury (DILI) across the world. Ibuprofen is one of the most c ...
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Source: PubMed
Molecules
Hepatotoxicity Modeling Using Counter-Propagation Artificial Neural Networks: Handling an Imbalanced Classification Problem.
Bajželj B, Drgan V
Drug-induced liver injury is a major concern in the drug development process. Expensive and time-consuming in vitro and in vivo studies do not reflect ...
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Source: PubMed
