J Huntingtons Dis 2020 Jan 28
Transcriptional Assessment of Striatal mRNAs as Valid Biomarkers of Disease Progression in Three Mouse Models of Huntington's Disease.
Ghavami A, Olsen M, Kwan M, Beltran J, Shea J, Ramboz S, Duan W, Lavery D, Howland D, Park LC
Huntington's disease (HD) is a progressive neurodegenerative disorder that prominently affects the basal ganglia, leading to affective, cognitive, beh ...
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Source: PubMed
Cancer Causes Control 2020 Jan 31
Allergy, asthma, and the risk of breast and prostate cancer: a Mendelian randomization study.
Jiang X, Dimou NL, Zhu Z, Bonilla C, Lewis SJ, Lindström S, Kraft P, Tsilidis KK, Martin RM
The relationship of allergic diseases, such as asthma, hay fever, and eczema, with cancer is under debate. Observational studies have reported conflic ...
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Source: PubMed
Parkinsonism Relat. Disord.
Co-Existence of tau and a-synuclein pathology in fetal graft tissue at autopsy: A case report.
Ornelas AS, Adler CH, Serrano GE, Curry JR, Shill HA, Kopyov O, Beach TG
Transplant of fetal ventral mesencephalic tissue into the striatum of Parkinson's disease (PD) patients has been performed to increase dopamine produc ...
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Source: PubMed
Neuron 2020 Jan 24
Genome-wide In Vivo CNS Screening Identifies Genes that Modify CNS Neuronal Survival and mHTT Toxicity.
Wertz MH, Mitchem MR, Pineda SS, Hachigian LJ, Lee H, Lau V, Powers A, Kulicke R, Madan GK, Colic M, Therrien M, Vernon A, Beja-Glasser VF, Hegde M, Gao F, Kellis M, Hart T, Doench JG, Heiman M
Unbiased in vivo genome-wide genetic screening is a powerful approach to elucidate new molecular mechanisms, but such screening has not been possible ...
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Source: PubMed
Biostatistics 2020 Jan 30
Estimating disease onset from change points of markers measured with error.
Lee U, Carroll RJ, Marder K, Wang Y, Garcia TP
Huntington disease is an autosomal dominant, neurodegenerative disease without clearly identified biomarkers for when motor-onset occurs. Current stan ...
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Source: PubMed
