Aging Cell 2020 Jan 25
Tissue specificity of senescent cell accumulation during physiologic and accelerated aging of mice.
Yousefzadeh MJ, Zhao J, Bukata C, Wade EA, McGowan SJ, Angelini LA, Bank MP, Gurkar AU, McGuckian CA, Calubag MF, Kato JI, Burd CE, Robbins PD, Niedernhofer LJ
Senescent cells accumulate with age in vertebrates and promote aging largely through their senescence-associated secretory phenotype (SASP). Many type ...
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Source: PubMed
Nat Commun
Endothelial progeria induces adipose tissue senescence and impairs insulin sensitivity through senescence associated secretory phenotype.
Barinda AJ, Ikeda K, Nugroho DB, Wardhana DA, Sasaki N, Honda S, Urata R, Matoba S, Hirata KI, Emoto N
Vascular senescence is thought to play a crucial role in an ageing-associated decline of organ functions; however, whether vascular senescence is caus ...
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Source: PubMed
Aerosp Med Hum Perform
Optic Nerve Tortuosity on Earth and in Space.
Scott RA, Tarver WJ, Brunstetter TJ, Urquieta E
INTRODUCTION: Spaceflight Associated Neuro-ocular Syndrome (SANS) results from long-duration spaceflight and presents with a constellation of signs (e ...
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Source: PubMed
Comput Struct Biotechnol J
G Protein-Coupled Receptor Systems and Their Role in Cellular Senescence.
Santos-Otte P, Leysen H, van Gastel J, Hendrickx JO, Martin B, Maudsley S
Aging is a complex biological process that is inevitable for nearly all organisms. Aging is the strongest risk factor for development of multiple neur ...
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Source: PubMed
Trends Cell Biol. 2020 Jan 06
Protecting the Aging Genome.
Petr MA, Tulika T, Carmona-Marin LM, Scheibye-Knudsen M
Mounting evidence suggests that DNA damage plays a central role in aging. Multiple tiers of defense have evolved to reduce the accumulation of DNA dam ...
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Source: PubMed
