Stem Cell Rev Rep 2020 Feb 01
Characterization of an Anti-CD5 Directed CAR T-Cell against T-Cell Malignancies.
Wada M, Zhang H, Fang L, Feng J, Tse CO, Zhang W, Chen Q, Sha S, Cao Y, Chen KH, Pinz KG, Chen X, Fan XX, Jiang X, Ma Y
T-cell malignancies often result in poor prognosis and outcome for patients. Immunotherapy has recently emerged as a revolutionary treatment against c ...
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Source: PubMed
Heart Fail Rev 2020 Feb 01
Effects of statins on the biological features of mesenchymal stem cells and therapeutic implications.
Gorabi AM, Kiaie N, Pirro M, Bianconi V, Jamialahmadi T, Sahebkar A
Statins are well-known lipid-lowering drugs. The pleiotropic effects of statins have brought about some beneficial effects on improving the therapeuti ...
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Source: PubMed
J. Clin. Immunol. 2020 Feb 01
Human BCL10 Deficiency due to Homozygosity for a Rare Allele.
Van Den Rym A, Taur P, Martinez-Barricarte R, Lorenzo L, Puel A, Gonzalez-Navarro P, Pandrowala A, Gowri V, Safa A, Toledano V, Cubillos-Zapata C, López-Collazo E, Vela M, Pérez-Martínez A, Sánchez-Ramón S, Recio MJ, Casanova JL, Desai MM, Perez de Diego R
In 2014, a child with broad combined immunodeficiency (CID) who was homozygous for a private BCL10 allele was reported to have complete inherited huma ...
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Source: PubMed
Aging (Albany NY)
CSF1R inhibitor PLX5622 and environmental enrichment additively improve metabolic outcomes in middle-aged female mice.
Ali S, Mansour AG, Huang W, Queen NJ, Mo X, Anderson JM, Hassan Ii QN, Patel RS, Wilkins RK, Caligiuri MA, Cao L
As the elderly population grows, chronic metabolic dysfunction including obesity and diabetes are becoming increasingly common comorbidities. Hypothal ...
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Source: PubMed
Aging (Albany NY)
High expression of SMYD3 indicates poor survival outcome and promotes tumour progression through an IGF-1R/AKT/E2F-1 positive feedback loop in bladder cancer.
Wang G, Huang Y, Yang F, Tian X, Wang K, Liu L, Fan Y, Li X, Li L, Shi B, Hao Y, Xia C, Nie Q, Xin Y, Shi Z, Ma L, Xu D, Liu C
The AKT/mTOR pathway is critical for bladder cancer (BC) pathogenesis and is hyper-activated during BC progression. In the present study, we identifie ...
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Source: PubMed
