A collection of symptoms in response to excess serotonin on the central or peripheral nervous system. The symptoms include cognitive, autonomic and somatic effects. Serotonin is a chemical synthesized in the body to enable brain cells and nerve cells to communicate with one another. Too much of it can cause excessive nerve cell activity.
Cause(s) :
Medications such as antidepressants, that affect the body’s level of serotonin
Opioids
Psychedelics
Symptoms :
Agitation or restlessness
Dilated pupils
Changes in blood pressure or temperature
Nausea, vomiting, diarrhea
Increased heart rate
Tremor, twitching of muscles
Shivering and goose bumps
Confusion
In severe cases:
High fever
Seizures
Irregular heartbeat
Excessive sweating
Unconsciousness
Diagnosis and Tests :
Diagnostic criteria:
Involuntary, rhythmic muscular contractions and relaxations (clonus) that are spontaneous, inducible or ocular
Tremor plus hyperreflexia or hypertonism plus high temperature with clonus
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