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Sezary Syndrome

Written by Himabindhu
Medically Reviewed by The Medindia Medical Review Team on Apr 03, 2015
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Other Names :  

Sézary’s disease, Sézary syndrome

What is Sezary Syndrome ?  

An aggressive form of cutaneous T-cell lymphoma. A type of immune cells called T-cells become cancerous and this type of cancer predominantly affects the skin. These cancerous cells can spread to other organs in the body like lymph nodes, liver, spleen and bone marrow.


Cause(s) :  
  • Unknown
Symptoms :  
  • Red, itchy rash on skin that covers large portions of the body
  • Formation of cancerous T-cells called Sézary cells on the skin. These cells have an abnormally shaped nucleus called cerebriform
  • Enlarged lymph nodes
  • Hair loss
  • Thickened skin on the palms and soles of feet
  • Abnormalities of fingernails and toenails
  • Outward turning of lower eyelids
Diagnosis and Tests :  
  • Skin lesions that do not heal with normal medication
  • Skin lesion biopsy
  • Blood tests
Specialist to consult :  Oncology-Medical



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