Dubin-johnson Syndrome

Written by Himabindhu

Medically Reviewed by The Medindia Medical Review Team on Apr 03, 2015

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What is Dubin-johnson Syndrome ?

Autosomal recessive disorder. The condition causes an increase of conjugated bilirubin in the serum without elevation of liver enzymes. There is a difficulty in the ability of hepatocytes to secrete conjugated bilirubin into the bile.

Cause(s) : Autosomal recessive gene disorder due to loss of function mutation Symptoms and signs: Usually asymptomatic, but may be diagnosed with tests in infancy.

Diagnosis and Tests :

Liver tests
Darkly pigmented liver (due to polymerized epinephrine metabolites)
Blood test
Urine tests for porphyrins
Autopsy of liver (reveals dark pink or black appearance due to pigment accumulation)

Specialist to consult : Pediatrics

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