6 Men Consume 6000 Calories a Day To Know Why Overeating Causes Diabetes

Though its is widely known that obesity is directly linked to the development of Type-II diabetes, still the main reason for its cause remains unknown.

Though it's widely known that obesity is directly linked to the development of Type-II diabetes, still the main reason for its cause is unknown. Therefore to find some clues regarding it, six volunteers were fed with two and a half times more than their daily intake at a hospital in Philadelphia.

Guenther Boden and Salim Merali at Temple University, Philadelphia along with colleagues investigated how overeating might lead to insulin resistance. They fed six healthy male volunteers 6000 calories of food every day for a week. This was around two and a half times what they should have been eating.

Overeating and Sugar Addiction Linked to Brain Circuit
Overeating and sugar addiction is found to be due to a brain circuit. The reward-related neural circuit specifically controls compulsive sugar consumption in mice.

“It was a regular, American diet, composed of pizzas, hamburgers and that sort of thing,” says Merali. All the volunteers were carefully monitored and were also prevented from exercising. By the end of the week, each volunteer was around 3.5 kilograms heavier than when they started.

Boden and Merali’s team noticed that the volunteers were urinating increasing amounts of oxidized lipid compounds, which are caused by reactive oxygen species attacking cell membranes, and are a hallmark of oxidative stress within the body.

Researchers suggested that the oxidative stress caused by overeating hampers blood sugar regulation because it changes the structure of a protein that is normally responsible for taking glucose out of the bloodstream.

Overeating can Prove Harmful for Type 2 Diabetes Patients
Overeating during a holiday get together could be harmful for people who suffer from Type 2 Diabetes, claims a new study.

“When the group looked closer, they could see the signs of this stress in biopsies of the volunteers’ fat tissue. This seems to be the beginning of the process that leads to insulin resistance. Insulin sends the same message, but the glucose is not removed from the blood. This is a brand new way to get from over-nutrition to insulin resistance,” says Boden.

“It’s a pretty cool finding. Oxidative stress and a damaged glucose-transporting protein may be the most important factor in insulin resistance, although other mechanisms are probably still involved. Overeating can also cause fat to build up in muscles and the liver – we still don’t know the mechanisms behind this,” said Francis Stephen at the University of Nottingham, UK.

Variety of Different Foods Could Aggravate Obesity
A research indicates that without a mother's diet, a strong factor to indicate obesity, children are more likely develop health related problems.

“Both the altered glucose-transporting protein and oxidative stress could be targets for future treatments,” said Boden.

Source-Medindia

Watching Hollywood Action Flicks on TV may Trigger Overeating
A new study suggests that watching TV shows filled with action and sound may be bad for your waistline.