The mechanisms underlying treatment resistance in children with T-cell acute lymphoblastic leukemia (T-ALL) have been identified by researchers.
Intermittent Fasting can Kill Cancer Cells of Childhood Leukemia
Acute lymphoblastic leukemia, the most common type of leukemia found in children, can occur at any age. Acute myeloid leukemia (AML) is more common in adults.
Acute lymphoblastic leukemia, the most common type of leukemia found in children, can occur at any age. Acute myeloid leukemia (AML) is more common in adults.
‘Inhibition of MEK-ERK or PI3K/AKT/mTOR signaling could enhance steroid sensitivity in children with T-cell acute lymphoblastic leukemia (T-ALL) and potentially improve patient outcomes.’
As described in their Research Article, Meijerink and
colleagues studied genetic changes in leukemic cells from pediatric
T-ALL patients before treatment. The researchers found specific gene
mutations affecting signaling inside cells, involving the interleukin 7
receptor and downstream molecules, that were associated with steroid
resistance and adverse clinical outcome. Drugs designed to target
individual signaling proteins were able to restore steroid sensitivity
to primary leukemic cells from patients. Discussing the research in an accompanying Perspective article, Steven Goossens and Pieter Van Vlierberghe conclude that "inhibition of MEK-ERK or PI3K/AKT/mTOR signaling could enhance steroid sensitivity in T-ALL and potentially improve patient outcomes, a notion that warrants investigation in future prospective clinical trials."
Source-Eurekalert
In Hispanic Patients Hereditary Risk Factors for Childhood Leukemia Are More Common
In comparison to other racial and ethnic backgrounds Hispanic kids are more likely to be diagnosed with acute lymphoblastic leukemia (ALL) and are more likely to die of their disease.
In comparison to other racial and ethnic backgrounds Hispanic kids are more likely to be diagnosed with acute lymphoblastic leukemia (ALL) and are more likely to die of their disease.
Abnormal Gene That Launches Rare Childhood Leukemia Identified By Gene Sequencing Project
Research has identified a fusion gene responsible for almost 30 percent of of a rare subtype of childhood leukemia with an extremely poor prognosis.
Research has identified a fusion gene responsible for almost 30 percent of of a rare subtype of childhood leukemia with an extremely poor prognosis.
New Treatment Options for High-Risk Childhood Leukemia Subtype Via Existing Drugs
New genetic alterations underlying a high-risk subtype of the most common childhood cancer have been identified by scientists.
New genetic alterations underlying a high-risk subtype of the most common childhood cancer have been identified by scientists.
