Gender and a family history of alcoholism (FH) are two genetically determined factors known to affect someone's risk for developing alcohol-use disorders (AUDs).

‘Adolescent females chose to drink at lower mean arterial Blood Alcohol Concentrations (BACs), because they experienced adverse alcohol effects, such as sedation, at lower BACs than men.’

Researchers asked 82 adolescents (47 males, 35 females) to report their real-life drinking in a TimeLine Follow-Back interview. The adolescents then participated in an experimental session of free-access intravenous Alcohol Self-Administration (ASA), using a computer-assisted alcohol infusion system that controlled for environmental cues as well as biological differences in alcohol pharmacokinetics. During the ASA, study authors assessed the participants' subjective alcohol effects at eight time points. 




During the interviews, the females reported significantly less real-life drinking than the males and, in the laboratory, achieved significantly lower mean arterial Blood Alcohol Concentrations (BACs), reported greater sedation, and rated negative effects as high as the males. The authors believe that adolescent women chose lower BACs because they experienced adverse alcohol effects, such as sedation, at lower BACs than men. A positive FH did not appear to be a risk factor for drinking for this sample.
Source-Newswise